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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition).自噬监测分析方法使用和解释的指南（第 4 版）。
Autophagy. 2021 Jan;17(1):1-382. doi: 10.1080/15548627.2020.1797280. Epub 2021 Feb 8.
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Endoplasmic reticulum stress and protein degradation in chronic liver disease.内质网应激与慢性肝病中的蛋白质降解。
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Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins.溶酶体功能在损伤后得到恢复，同时伴随着溶酶体膜蛋白的循环利用。
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The gene for the lysosomal protein LAMP3 is a direct target of the transcription factor ATF4.溶酶体蛋白 LAMP3 的基因是转录因子 ATF4 的直接靶标。
J Biol Chem. 2020 May 22;295(21):7418-7430. doi: 10.1074/jbc.RA119.011864. Epub 2020 Apr 20.
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Endothelial cell pyroptosis plays an important role in Kawasaki disease via HMGB1/RAGE/cathespin B signaling pathway and NLRP3 inflammasome activation.内皮细胞焦亡通过 HMGB1/RAGE/cathepsin B 信号通路和 NLRP3 炎性小体激活在川崎病中发挥重要作用。
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Discrepancy of Serological and Molecular Patterns of Circulating Epstein-Barr Virus Reactivation in Primary Sjögren's Syndrome.原发性干燥综合征中血清学和循环 EBV 再激活的分子模式差异。
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LAMP3 通过溶酶体膜通透性抑制自噬并促进细胞死亡。

LAMP3 inhibits autophagy and contributes to cell death by lysosomal membrane permeabilization.

机构信息

Adeno-Associated Virus Biology Section, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

Salivary Disorders Unit, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD, USA.

出版信息

Autophagy. 2022 Jul;18(7):1629-1647. doi: 10.1080/15548627.2021.1995150. Epub 2021 Nov 22.

DOI:10.1080/15548627.2021.1995150
PMID:34802379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9298453/
Abstract

A253-control: A253 control for LAMP3 stable overexpression; A253- LAMP3: A253 LAPM3 stable overexpression; CASP1: caspase 1; CASP3: caspase 3; CHX: cycloheximide; CTSB: cathepsin B; CTSD: cathepsin D; CQ: chloroquine; DCs: dendritic cells; ER: endoplasmic reticulum; LGALS3: galectin 3; HCV: hepatitis C virus; HSG-control: HSG control for LAMP3 stable overexpression; HSG-LAMP3: HSG LAMP3 stable overexpression; HSP: heat shock protein; HTLV-1: human T-lymphocyte leukemia virus-1; IXA: ixazomib; LAMP: lysosomal associated membrane protein; MHC: major histocompatibility complex; mAb: monoclonal antibody; OE: overexpression; pepA: pepstatin A; pAb: polyclonal antibody; pSS: primary Sjögren syndrome; qRT-PCR: quantitative real- time reverse transcriptase polymerase chain reaction; SLE: systemic lupus erythematosus; SS: Sjögren syndrome; UPR: unfolded protein response; V-ATPase: vacuolar-type proton- translocating ATPase; Y-VAD: Ac-YVAD-cmk; Z-DEVD; Z-DEVD-fmk; Z-VAD: Z-VAD- fmk.

摘要

A253-control：用于 LAMP3 稳定过表达的 A253 对照；A253-LAMP3：A253 LAPM3 稳定过表达；CASP1：半胱天冬酶 1；CASP3：半胱天冬酶 3；CHX：环己酰亚胺；CTSB：组织蛋白酶 B；CTSD：组织蛋白酶 D；CQ：氯喹；DCs：树突状细胞；ER：内质网；LGALS3：半乳糖凝集素 3；HCV：丙型肝炎病毒；HSG-control：用于 LAMP3 稳定过表达的 HSG 对照；HSG-LAMP3：HSG LAMP3 稳定过表达；HSP：热休克蛋白；HTLV-1：人类 T 淋巴细胞白血病病毒 1；IXA：依沙佐米；LAMP：溶酶体相关膜蛋白；MHC：主要组织相容性复合体；mAb：单克隆抗体；OE：过表达；pepA：胃蛋白酶抑制剂 A；pAb：多克隆抗体；pSS：原发性干燥综合征；qRT-PCR：实时定量逆转录聚合酶链反应；SLE：系统性红斑狼疮；SS：干燥综合征；UPR：未折叠蛋白反应；V-ATPase：液泡型质子转运 ATP 酶；Y-VAD：Ac-YVAD-cmk；Z-DEVD；Z-DEVD-fmk；Z-VAD：Z-VAD-fmk。