GVM Care & Research, Department of Cardiovascular Surgery, Anthea Hospital, Via Camillo Rosalba, 35/38, Bari, Italy.
Department of Experimental and Clinical Medicine, Magna Graecia University, Catanzaro, Italy.
J Cardiothorac Surg. 2021 Nov 21;16(1):338. doi: 10.1186/s13019-021-01723-4.
This study was conducted to compare the outcomes of prosthetic ring versus autologous pericardial strip for the treatment of functional tricuspid regurgitation during left-sided valve surgery by minimally invasive approach.
From January 2008 and July 2016, autologous pericardial strip (group P-TAP) was used in 109 patients, and prosthetic ring (group R-TAP) in 115 patients. The primary outcomes were long-term overall survival, development of patch degeneration, and significant tricuspid regurgitation recurrence. The second outcome was the assessment of right ventricular functional parameters.
Operative mortality was 1 case (0.9%) in the R-TAP group. At the time of hospital discharge only one patient (0.9%) in the R-TAP group had grade III+ tricuspid regurgitation, and none had grade IV+. Mean follow-up was 94.1 ± 24.5 months. Mild and moderate tricuspid regurgitation recurrence was 3.7% and 4.5% (P-TAP vs. R-TAP groups, p = 0.99). Severe regurgitation was observed in 1.8% of cases only in the R-TAP group (p = 0.49). There were no reoperations. Late mortality was 3.7% and 5.4% (P-TAP vs. R-TAP groups, p = 0.75). Freedom from death, all causes, were comparable among groups (log-rank p = 0.45). There were no statistically significant differences between two groups in TAPSE, left ventricular end-diastolic diameter, left ventricular ejection fraction, and left atrial diameter.
Tricuspid annuloplasty using an autologous pericardial strip in patients undergoing minimally invasive surgery is associated to similar long results (survival, late tricuspid regurgitation, and functional echocardiographic parameters) than annuloplasty with a prosthetic ring. In particular, the pericardial strip over time does not develop any degeneration or retraction.
本研究旨在比较微创左心瓣膜手术中使用人工生物补片环(R-TAP)和自体心包条带(P-TAP)治疗功能性三尖瓣反流的效果。
2008 年 1 月至 2016 年 7 月,109 例患者接受了自体心包条带(P-TAP)治疗,115 例患者接受了人工生物补片环(R-TAP)治疗。主要终点为长期总生存率、补片退化和重度三尖瓣反流复发。次要终点为右心室功能参数的评估。
R-TAP 组的手术死亡率为 1 例(0.9%)。出院时,仅 R-TAP 组有 1 例(0.9%)患者出现 III+级三尖瓣反流,无 IV+级反流。平均随访时间为 94.1±24.5 个月。轻度和中度三尖瓣反流复发率分别为 3.7%和 4.5%(P-TAP 组与 R-TAP 组,p=0.99)。仅 R-TAP 组有 1.8%的患者出现重度反流(p=0.49)。无再次手术。晚期死亡率分别为 3.7%和 5.4%(P-TAP 组与 R-TAP 组,p=0.75)。各组之间的全因死亡率无统计学差异(log-rank p=0.45)。两组间 TAPSE、左心室舒张末期直径、左心室射血分数和左心房直径无统计学差异。
微创心脏瓣膜手术中使用自体心包条带进行三尖瓣环成形术与使用人工生物补片环相比,具有相似的长期结果(生存率、晚期三尖瓣反流和功能超声心动图参数)。此外,心包条带在使用过程中不会发生任何退化或回缩。