Potential risks of tumor virus subgenomes in the production of biologicals.

In this report, an attempt was made to describe what is presently known about the biological activities of tumor virus DNAs, their regulatory regions, and some factors which interplay with their oncogenic potential. In light of current knowledge, it is likely that the gene transfer risks of using continuous cell lines expressing known oncogenes, or cells containing oncogenic virus-recombinant DNA vectors, are minimal.