脂肪细胞外囊泡：心脏线粒体应激的拯救者
Adipocyte extracellular vesicles: rescuers of cardiac mitochondrial stress.
作者信息
Loyer Xavier, Boulanger Chantal M, Le Lay Soazig
机构信息
Université de Paris, Inserm, PARCC, F-75015 Paris, France.
Université de Nantes, CNRS, INSERM, l'Institut du Thorax, F-44000 Nantes, France; Université d'Angers, SFR ICAT, F-49000 Angers, France.
出版信息
Trends Endocrinol Metab. 2022 Jan;33(1):1-3. doi: 10.1016/j.tem.2021.11.001. Epub 2021 Nov 18.
Nutrient excess induces mitochondrial dysfunction, which participates in obesity-related complications. Obesity also associates with high cardiac oxidative stress, which contributes to myocardial dysfunction. Crewe et al. recently evidenced the pivotal role of adipocyte-derived extracellular vesicles (EVs) in cardiac oxidative stress responses and revealed their unexpected protective effect against ischemia/reperfusion injury.
营养过剩会导致线粒体功能障碍，这与肥胖相关并发症有关。肥胖还与心脏氧化应激水平升高有关，而氧化应激会导致心肌功能障碍。克鲁等人最近证实了脂肪细胞衍生的细胞外囊泡（EVs）在心脏氧化应激反应中的关键作用，并揭示了它们对缺血/再灌注损伤具有意想不到的保护作用。
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