Romagnano M A, Braiman J, Loomis M, Hamill R W
Neurology Unit, Monroe Community Hospital, Rochester, New York 14603.
J Comp Neurol. 1987 Dec 15;266(3):319-31. doi: 10.1002/cne.902660303.
The present studies in the rat employ spinal transections and hemisections, dorsal and/or ventral rhizotomies to determine whether enkephalin fibers in spinal sympathetic and parasympathetic nuclei are of supraspinal, intraspinal, or peripheral origin. Our results suggest enkephalin fibers in thoracolumbar sympathetic nuclei are of both supraspinal and intraspinal origin, whereas the enkephalin innervation of the sacral parasympathetic nucleus is primarily intraspinal in origin. Furthermore, the majority of descending enkephalin systems selectivity project to the intermediolateralis, pars principalis and pars funicularis, and the dorsal commissural sympathetic nuclei, whereas intraspinal enkephalin pathways appear to exist primarily in the intercalatus spinalis and intercalatus spinalis, pars paraependymalis sympathetic nuclei. These new observations suggest that specific patterns exist for supraspinal and intraspinal enkephalin pathways.
目前在大鼠身上进行的研究采用脊髓横断术和半横断术、背侧和/或腹侧神经根切断术，以确定脊髓交感神经核和副交感神经核中的脑啡肽纤维是源于脊髓上、脊髓内还是外周。我们的结果表明，胸腰段交感神经核中的脑啡肽纤维源于脊髓上和脊髓内，而骶副交感神经核的脑啡肽神经支配主要源于脊髓内。此外，大多数下行脑啡肽系统选择性地投射到中间外侧核、主部和索部，以及背侧连合交感神经核，而脊髓内脑啡肽通路似乎主要存在于脊髓中间插入核和脊髓中间插入核室管膜旁交感神经核。这些新观察结果表明，脊髓上和脊髓内脑啡肽通路存在特定模式。
