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Metformin for the management of tuberous sclerosis: What does the evidence tell us?

作者信息

Srinivasan Anirudh, Naga Shashi Kiran Beti, Koduvath Abdulla, Pal Auroprakash, Suresh Ananthu, Kannan Amudhan, Ravichandran Mirunalini

机构信息

Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, India.

出版信息

EXCLI J. 2021 Sep 27;20:1474-1475. doi: 10.17179/excli2021-4213. eCollection 2021.

Abstract
摘要

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The metformin in tuberous sclerosis (MiTS) study: A randomised double-blind placebo-controlled trial.
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The journey of metformin from glycaemic control to mTOR inhibition and the suppression of tumour growth.
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mTOR Inhibitors in Tuberous Sclerosis Complex.
Curr Neuropharmacol. 2012 Dec;10(4):404-15. doi: 10.2174/157015912804143595.
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Tuberous sclerosis complex: a review of the management of epilepsy with emphasis on surgical aspects.
Childs Nerv Syst. 2006 Aug;22(8):896-908. doi: 10.1007/s00381-006-0130-7. Epub 2006 Jun 13.
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Managing epilepsy in tuberous sclerosis complex.
J Child Neurol. 2004 Sep;19(9):680-6. doi: 10.1177/08830738040190090801.
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Non-penetrance in tuberous sclerosis.
Lancet. 2000 May 13;355(9216):1698. doi: 10.1016/s0140-6736(00)02247-9.

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