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IL-4 产生的 Vγ1/Vδ6 γδ T 细胞在小鼠派氏集合淋巴结中维持生发中心反应。

IL-4-Producing Vγ1/Vδ6 γδ T Cells Sustain Germinal Center Reactions in Peyer's Patches of Mice.

机构信息

Institute of Immunology, Hannover Medical School, Hannover, Germany.

Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan.

出版信息

Front Immunol. 2021 Nov 3;12:729607. doi: 10.3389/fimmu.2021.729607. eCollection 2021.

DOI:10.3389/fimmu.2021.729607
PMID:34804014
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8600568/
Abstract

The mucosal immune system is the first line of defense against pathogens. Germinal centers (GCs) in the Peyer's patches (PPs) of the small intestine are constantly generated through stimulation of the microbiota. In this study, we investigated the role of γδ T cells in the GC reactions in PPs. Most γδ T cells in PPs localized in the GCs and expressed a TCR composed of Vγ1 and Vδ6 chains. By using mice with partial and total γδ T cell deficiencies, we found that Vγ1/Vδ6 T cells can produce high amounts of IL-4, which drives the proliferation of GC B cells as well as the switch of GC B cells towards IgA. Therefore, we conclude that γδ T cells play a role in sustaining gut homeostasis and symbiosis supporting the GC reactions in PPs.

摘要

黏膜免疫系统是抵御病原体的第一道防线。小肠派尔集合淋巴结（PPs）中的生发中心（GCs）通过刺激微生物群不断产生。在这项研究中，我们研究了 γδ T 细胞在 PPs 中的 GC 反应中的作用。PPs 中的大多数 γδ T 细胞定位于 GCs 中，并表达由 Vγ1 和 Vδ6 链组成的 TCR。通过使用部分和完全 γδ T 细胞缺陷的小鼠，我们发现 Vγ1/Vδ6 T 细胞可以产生大量的 IL-4，这可以驱动 GC B 细胞的增殖以及 GC B 细胞向 IgA 的转换。因此，我们得出结论，γδ T 细胞在维持肠道内稳态和共生关系中发挥作用，支持 PPs 中的 GC 反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/2c663a712670/fimmu-12-729607-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/da5fd3141d34/fimmu-12-729607-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/00bd252e2eba/fimmu-12-729607-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/bb16d5637aca/fimmu-12-729607-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/7782d30a9419/fimmu-12-729607-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/a4128ab9fde8/fimmu-12-729607-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/2c663a712670/fimmu-12-729607-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/da5fd3141d34/fimmu-12-729607-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/00bd252e2eba/fimmu-12-729607-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/bb16d5637aca/fimmu-12-729607-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/7782d30a9419/fimmu-12-729607-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/a4128ab9fde8/fimmu-12-729607-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2830/8600568/2c663a712670/fimmu-12-729607-g006.jpg

相似文献

[1]
IL-4-Producing Vγ1/Vδ6 γδ T Cells Sustain Germinal Center Reactions in Peyer's Patches of Mice.

Front Immunol. 2021

[2]
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[3]
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[4]
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[5]
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[6]
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[7]
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[8]
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[9]
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[10]
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引用本文的文献

[1]
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Front Immunol. 2025-8-1

[2]
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Elife. 2025-7-23

[3]
Immune age is correlated with decreased TCR clonal diversity and antibody response to SARS-CoV-2.

Sci Rep. 2025-6-6

[4]
The peptidoglycan-associated lipoprotein gene mutant elicits robust immunological defense in mice against .

Front Microbiol. 2024-6-5

[5]
Human γδ T cells in diverse tissues exhibit site-specific maturation dynamics across the life span.

Sci Immunol. 2024-6-7

[6]
The function of γδ T cells in humoral immune responses.

Inflamm Res. 2023-4

[7]
Gamma delta T-cell-based immune checkpoint therapy: attractive candidate for antitumor treatment.

Mol Cancer. 2023-2-15

[8]
Targeting Cytokine Signals to Enhance γδT Cell-Based Cancer Immunotherapy.

Front Immunol. 2022

[9]
Three Layers of Intestinal γδ T Cells Talk Different Languages With the Microbiota.

Front Immunol. 2022

本文引用的文献

[1]
Revisiting the Interaction of γδ T-Cells and B-Cells.

Cells. 2020-3-18

[2]
BAFF, IL-4 and IL-21 separably program germinal center-like phenotype acquisition, BCL6 expression, proliferation and survival of CD40L-activated B cells in vitro.

Immunol Cell Biol. 2019-7-29

[3]
BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses.

Mucosal Immunol. 2019-5-29

[4]
Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells.

J Exp Med. 2018-11-19

[5]
γδ T cells control humoral immune response by inducing T follicular helper cell differentiation.

Nat Commun. 2018-8-8

[6]
Deconstructing the germinal center, one cell at a time.

Curr Opin Immunol. 2017-4

[7]
Development and Function of Secondary and Tertiary Lymphoid Organs in the Small Intestine and the Colon.

Front Immunol. 2016-9-6

[8]
Peyer's patches: organizing B-cell responses at the intestinal frontier.

Immunol Rev. 2016-5

[9]
γδ T Cells Shape Preimmune Peripheral B Cell Populations.

J Immunol. 2016-1-1

[10]
Dynamics of B cells in germinal centres.

Nat Rev Immunol. 2015-3

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