Zhang Haihong, Wang Yanli, Feng Jinghui, Wang Shuya, Wang Yan, Kong Weisi, Zhang Zhiyi
Department of Rheumatology and Immunology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Department of Gerontology, The First Affiliated Hospital of Harbin Medical University, Harbin, China.
Front Genet. 2021 Nov 4;12:782005. doi: 10.3389/fgene.2021.782005. eCollection 2021.
Systemic lupus erythematosus (SLE) is a complex and heterogeneous autoimmune disease that the immune system attacks healthy cells and tissues. SLE is difficult to get a correct and timely diagnosis, which makes its morbidity and mortality rate very high. The pathogenesis of SLE remains to be elucidated. To clarify the potential pathogenic mechanism of SLE, we performed an integrated analysis of two RNA-seq datasets of SLE. Differential expression analysis revealed that there were 4,713 and 2,473 differentially expressed genes, respectively, most of which were up-regulated. After integrating differentially expressed genes, we identified 790 common differentially expressed genes (DEGs). Gene functional enrichment analysis was performed and found that common differentially expressed genes were significantly enriched in some important immune-related biological processes and pathways. Our analysis provides new insights into a better understanding of the pathogenic mechanisms and potential candidate markers for systemic lupus erythematosus.
系统性红斑狼疮（SLE）是一种复杂的异质性自身免疫性疾病，免疫系统会攻击健康细胞和组织。SLE难以得到正确及时的诊断，这导致其发病率和死亡率很高。SLE的发病机制仍有待阐明。为了阐明SLE潜在的致病机制，我们对两个SLE的RNA测序数据集进行了综合分析。差异表达分析显示，分别有4713个和2473个差异表达基因，其中大多数是上调的。整合差异表达基因后，我们鉴定出790个共同差异表达基因（DEG）。进行了基因功能富集分析，发现共同差异表达基因在一些重要的免疫相关生物学过程和途径中显著富集。我们的分析为更好地理解系统性红斑狼疮的致病机制和潜在候选标志物提供了新的见解。
