胰腺癌伴发的副肿瘤性肌病：一例报告及文献复习
Paraneoplastic myopathy in pancreatic cancer: a case report and literature review.
作者信息
Padniewski Jessica Joanne, Nelson Elizabeth, Mian Istiaq, Laczniak Andrew, Ives Samuel, Nasr Rawad
机构信息
Department of Medicine , Hennepin Healthcare Internal Medicine Residency, Minneapolis, MN, USA.
Department of Medicine, SSM Health, Madison, WI, USA.
出版信息
J Community Hosp Intern Med Perspect. 2021 Nov 15;11(6):847-851. doi: 10.1080/20009666.2021.1982487. eCollection 2021.
Dermatomyositis (DM) and polymyositis (PM) are both immune-mediated inflammatory myopathies known to occur in paraneoplastic syndromes associated with a new diagnosis of malignancy, most commonly breast, ovarian, lung, pancreatic, stomach, colorectal, and Non-Hodgkin's lymphoma in DM and breast, lung, bladder cancer, and Non-Hodgkin's lymphoma in PM. While inflammatory markers such as creatine kinase (CK) may be elevated with either DM or PM, marked elevation is rare. Herein, we report a case of newly diagnosed pancreatic cancer presenting with inflammatory myopathy and marked CK elevation. We review the frequency of PM as a paraneoplastic syndrome, the association with marked CK elevation, and the association with pancreatic cancer.
皮肌炎（DM）和多发性肌炎（PM）均为免疫介导的炎性肌病，已知可发生于与新诊断恶性肿瘤相关的副肿瘤综合征中，在皮肌炎中最常见于乳腺癌、卵巢癌、肺癌、胰腺癌、胃癌、结直肠癌和非霍奇金淋巴瘤，在多发性肌炎中最常见于乳腺癌、肺癌、膀胱癌和非霍奇金淋巴瘤。虽然肌酸激酶（CK）等炎症标志物在皮肌炎或多发性肌炎中可能升高，但显著升高较为罕见。在此，我们报告一例新诊断的胰腺癌患者，其表现为炎性肌病且肌酸激酶显著升高。我们回顾了多发性肌炎作为副肿瘤综合征的发生率、与肌酸激酶显著升高的关联以及与胰腺癌的关联。
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