Ahl Ariel, Orphali Rafi, Desai Kumar
Internal Medicine Residency Program, HCA Los Robles Health System, 227 West Janns Road Thousand Oaks, CA 91360, United States.
Department of Gastroenterology/Hepatology, HCA Los Robles Health System, Thousand Oaks 91360, United States.
Oxf Med Case Reports. 2025 Aug 20;2025(8):omaf141. doi: 10.1093/omcr/omaf141. eCollection 2025 Aug.
Rhabdomyolysis is a clinical syndrome characterized by the breakdown of skeletal muscle tissue, leading to the release of myoglobin and creatine kinase (CK) into the bloodstream. The condition clinically presents with myalgia, weakness, and dark urine. It can lead to kidney failure and can be life threatening. Various factors and conditions, including trauma, prolonged immobilization, strenuous exercise, infections, alcohol consumption, medications, and malignancies are potential causes. A rare cause of pancreatic cancer-induced paraneoplastic myositis has been observed. Herein, we present the case of an 87-year-old man who presented with fatigue, weight loss, and invasive pancreatic adenocarcinoma resulting in rhabdomyolysis due to paraneoplastic myositis.
横纹肌溶解症是一种临床综合征,其特征是骨骼肌组织分解,导致肌红蛋白和肌酸激酶(CK)释放到血液中。该病症临床上表现为肌痛、虚弱和深色尿液。它可导致肾衰竭,甚至危及生命。多种因素和病症,包括创伤、长期固定、剧烈运动、感染、饮酒、药物和恶性肿瘤都是潜在病因。已观察到胰腺癌诱发副肿瘤性肌炎这一罕见病因。在此,我们报告一例87岁男性病例,该患者出现疲劳、体重减轻,并患有侵袭性胰腺腺癌,因副肿瘤性肌炎导致横纹肌溶解症。