Ghafouri-Fard Soudeh, Khoshbakht Tayyebeh, Taheri Mohammad, Jamali Elena
Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Phytochemistry Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Front Oncol. 2021 Nov 4;11:762960. doi: 10.3389/fonc.2021.762960. eCollection 2021.
CircPVT1 (hsa_circ_0001821) is a cancer-related circular RNA (circRNA) that originated from a genomic locus on chromosome 8q24. This locus has been previously found to encode the oncogenic long non-coding RNA PVT1. Expression of this circRNA has been found to be upregulated in diverse neoplastic conditions. CircPVT1 acts as a sponge for miR-125a, miR-125b, miR-124-3p, miR-30a-5p, miR-205-5p, miR-423-5p, miR-526b, miR-137, miR-145-5p, miR-497, miR-30d/e, miR-455-5p, miR-29a-3p, miR-204-5p, miR-149, miR-106a-5p, miR-377, miR-3666, miR-203, and miR-199a-5p. Moreover, it can regulate the activities of PI3K/AKT, Wnt5a/Ror2, E2F2, and HIF-1α. Upregulation of circPVT1 has been correlated with decreased survival of patients with different cancer types. In the current review, we explain the oncogenic impact of circPVT1 in different tissues based on evidence from , , and clinical investigations.
CircPVT1（hsa_circ_0001821）是一种与癌症相关的环状RNA（circRNA），起源于8号染色体q24上的一个基因组位点。此前已发现该位点编码致癌性长链非编码RNA PVT1。已发现这种circRNA在多种肿瘤性疾病中表达上调。CircPVT1可作为miR-125a、miR-125b、miR-124-3p、miR-30a-5p、miR-205-5p、miR-423-5p、miR-526b、miR-137、miR-145-5p、miR-497、miR-30d/e、miR-455-5p、miR-29a-3p、miR-204-5p、miR-149、miR-106a-5p、miR-377、miR-3666、miR-203和miR-199a-5p的海绵。此外，它还可以调节PI3K/AKT、Wnt5a/Ror2、E2F2和HIF-1α的活性。CircPVT1的上调与不同癌症类型患者的生存率降低相关。在本综述中，我们根据来自[具体文献1]、[具体文献2]和临床研究的证据，解释了circPVT1在不同组织中的致癌作用。
