Zhu Mengyi, Chen Daoyang, Ruan Chuangdong, Yang Penghui, Zhu Jinrong, Zhang Rongxin, Li Yan
Department of Biotechnology, School of Life Sciences and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou 510006, China.
Int J Mol Sci. 2023 Sep 17;24(18):14194. doi: 10.3390/ijms241814194.
CircRNAs are a class of endogenous long non-coding RNAs with a single-stranded circular structure. Most circRNAs are relatively stable, highly conserved, and specifically expressed in tissue during the cell and developmental stages. Many circRNAs have been discovered in OSCC. OSCC is one of the most severe and frequent forms of head and neck cancer today, with a poor prognosis and low overall survival rate. Due to its prevalence, OSCC is a global health concern, characterized by genetic and epigenomic changes. However, the mechanism remains vague. With the advancement of biotechnology, a large number of circRNAs have been discovered in mammalian cells. CircRNAs are dysregulated in OSCC tissues and thus associated with the clinicopathological characteristics and prognosis of OSCC patients. Research studies have demonstrated that circRNAs can serve as biomarkers for OSCC diagnosis and treatment. Here, we summarized the properties, functions, and biogenesis of circRNAs, focusing on the progress of current research on circRNAs in OSCC.
环状RNA（circRNAs）是一类具有单链环状结构的内源性长链非编码RNA。大多数环状RNA相对稳定、高度保守，且在细胞和发育阶段的组织中特异性表达。在口腔鳞状细胞癌（OSCC）中已发现许多环状RNA。OSCC是当今头颈部癌症中最严重且最常见的形式之一，预后较差，总体生存率较低。由于其普遍性，OSCC是一个全球健康问题，其特征是基因和表观基因组变化。然而，其机制仍不明确。随着生物技术的进步，在哺乳动物细胞中发现了大量环状RNA。环状RNA在OSCC组织中表达失调，因此与OSCC患者的临床病理特征和预后相关。研究表明，环状RNA可作为OSCC诊断和治疗的生物标志物。在此，我们总结了环状RNA的特性、功能和生物发生，重点关注环状RNA在OSCC中的当前研究进展。
