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皂苷通过调节肠道菌群的组成和多样性来改善大鼠炎症和 DSS 诱导的结肠炎。

Saponins Ameliorate Inflammation and DSS-Induced Ulcerative Colitis in Rats by Regulating the Composition and Diversity of Intestinal Flora.

机构信息

Key Laboratory of Depression Animal Model Based on Traditional Chinese Medicine (TCM) Syndrome, Jiangxi Administration of Traditional Chinese Medicine, Key Laboratory of TCM for Prevention and Treatment of Brain Diseases with Cognitive Impairment, Jiangxi University of Chinese Medicine, Nanchang, China.

Department of Pharmacy, Nanchang Medical College, Nanchang, China.

出版信息

Front Cell Infect Microbiol. 2021 Nov 5;11:728929. doi: 10.3389/fcimb.2021.728929. eCollection 2021.

DOI:10.3389/fcimb.2021.728929
PMID:34804990
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8602866/
Abstract

(Bunge) Regel is a commonly used Chinese medicine for clearing away heat and detoxification, cooling blood, stopping dysentery, and anti-inflammatory effects. saponins (PRS) have been identified to be responsible for producing these pharmacological activities. Studies have shown that Pulsatilla decoction has a good therapeutic effect on ulcerative colitis (UC), however, the therapeutic effect of PRS on UC has not been reported. Therefore, the purpose of this study was to investigate the possible anti-UC activity of PRS using a dextran sulfate sodium (DSS)-induced rat model, and further study the mechanism of PRS in the treatment of UC. The fecal and colon samples were collected from rats to monitor the changes in the composition and diversity of the intestinal flora, and pathological colon sections were also made to examine the mesenteric hemorheological characteristics. The results showed that PRS significantly reduced the mesenteric blood flow in UC rats and significantly alleviated the inflammatory response, which indicates that saponins are involved in the anti-UC effects of PRS. At the same time, it is also suggested that the regulation of intestinal flora by saponins is an important pathway for its anti-UC activity, which may be ascribed to the increase in beneficial bacteria like norank_F_Muribaculaceae and norank_F_norank_O_Clostridia_UCG-014, and decrease in the harmful Bacteroides.

摘要

（ Bunge ）白头翁是一种常用的中药，具有清热解毒、凉血止痢、抗炎等作用。已鉴定出皂苷（ PRS ）负责产生这些药理活性。研究表明，白头翁汤对溃疡性结肠炎（ UC ）有良好的治疗作用，然而， PRS 对 UC 的治疗作用尚未报道。因此，本研究旨在使用葡聚糖硫酸钠（ DSS ）诱导的大鼠模型研究 PRS 对 UC 的可能抗 UC 活性，并进一步研究 PRS 治疗 UC 的作用机制。从大鼠中收集粪便和结肠样本，以监测肠道菌群组成和多样性的变化，并制作病理结肠切片，以检查肠系膜血液流变学特征。结果表明， PRS 可显著降低 UC 大鼠的肠系膜血流量，显著缓解炎症反应，表明皂苷参与了 PRS 的抗 UC 作用。同时，这也表明皂苷对肠道菌群的调节是其抗 UC 活性的重要途径，这可能归因于有益菌如 norank_F_Muribaculaceae 和 norank_F_norank_O_Clostridia_UCG-014 的增加和有害菌 Bacteroides 的减少。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/1d8d4de8d075/fcimb-11-728929-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/adc94bd9d098/fcimb-11-728929-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/09514097a0cd/fcimb-11-728929-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/c6e26a94b260/fcimb-11-728929-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/68eea9f64d2f/fcimb-11-728929-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/f037d8084c26/fcimb-11-728929-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/c4eb20f74c26/fcimb-11-728929-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/a851d34cc749/fcimb-11-728929-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/fddb884e8ef6/fcimb-11-728929-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/af4488c4ae1d/fcimb-11-728929-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/a54348765e0d/fcimb-11-728929-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/d0ecebc4fad9/fcimb-11-728929-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/1d8d4de8d075/fcimb-11-728929-g012.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/adc94bd9d098/fcimb-11-728929-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/09514097a0cd/fcimb-11-728929-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/c6e26a94b260/fcimb-11-728929-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/68eea9f64d2f/fcimb-11-728929-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/f037d8084c26/fcimb-11-728929-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/c4eb20f74c26/fcimb-11-728929-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/a851d34cc749/fcimb-11-728929-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/fddb884e8ef6/fcimb-11-728929-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/af4488c4ae1d/fcimb-11-728929-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/a54348765e0d/fcimb-11-728929-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/d0ecebc4fad9/fcimb-11-728929-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/db40/8602866/1d8d4de8d075/fcimb-11-728929-g012.jpg

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本文引用的文献

[1]
Cryptotanshinone alleviates chemotherapy-induced colitis in mice with colon cancer via regulating fecal-bacteria-related lipid metabolism.

Pharmacol Res. 2021-1

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