Wang Wencan, Xu Ling, Cao Yong, Liu Guo, Zhang Yan, Wang Xi, Mao Xin
Chongqing Sweet Pet Products Co., Ltd., Chongqing, China.
Guangdong Provincial Key Laboratory of Nutraceuticals and Functional Foods, College of Food Science, South China Agricultural University, Guangzhou, China.
Front Microbiol. 2025 Aug 1;16:1587149. doi: 10.3389/fmicb.2025.1587149. eCollection 2025.
Krill oil (KO) is a bioactive substance with antioxidant and immunomodulatory functions. This study investigated the impact of administering snacks supplemented with 0.5% KO for 8 weeks on the blood parameters, hair quality, and fecal microbiota in dogs. KO was determined to elevate the activities of serum superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and immunoglobulin G (IgG) level. Concurrently, KO markedly diminished serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), interleukin-8 (IL-8), and malondialdehyde (MDA) levels in dogs. The KO group displayed a considerably higher ratio of ideal scores and thinner hair scales for newborn hair, as well as a significant increase in total amino acid and methionine (Met) content in comparison to the control group. Furthermore, 16S rRNA sequencing revealed the changes in the composition of fecal microbiota after KO feeding. KO significantly affected the α and β diversity of canine fecal microbiota. Moreover, KO augmented the relative abundance of Bacteroidota, Actinobacteriota, and Proteobacteria at the phylum level, and it increased the relative abundance of , , , , and at the genus level. In summary, this study provides valuable insights to further understand the role of KO in promoting canine health.
磷虾油（KO）是一种具有抗氧化和免疫调节功能的生物活性物质。本研究调查了连续8周给犬类喂食添加0.5% KO的零食对其血液参数、毛发质量和粪便微生物群的影响。结果发现，KO可提高犬血清超氧化物歧化酶（SOD）、过氧化氢酶（CAT）、谷胱甘肽过氧化物酶（GSH-Px）的活性以及免疫球蛋白G（IgG）水平。同时，KO显著降低了犬血清肿瘤坏死因子-α（TNF-α）、白细胞介素-1β（IL-1β）、白细胞介素-8（IL-8）和丙二醛（MDA）水平。与对照组相比，KO组新生毛发的理想评分比例更高，毛鳞片更薄，总氨基酸和蛋氨酸（Met）含量也显著增加。此外，16S rRNA测序揭示了喂食KO后粪便微生物群组成的变化。KO显著影响了犬粪便微生物群的α和β多样性。此外，KO在门水平上增加了拟杆菌门、放线菌门和变形菌门的相对丰度，在属水平上增加了 、 、 、 和 的相对丰度。总之，本研究为进一步了解KO在促进犬类健康中的作用提供了有价值的见解。
