Shareef Rawaa Hadi, Zwain Zinah Dhiaa, Mahbuba Wadhah Abdulhussian
Department of Pharmacology and Toxicology, College of Pharmacy, University of Kufa, Najaf, Iraq.
Medical Education Unit, College of Medicine, University of Kufa, Najaf, Iraq.
Heliyon. 2021 Nov;7(11):e08412. doi: 10.1016/j.heliyon.2021.e08412. Epub 2021 Nov 16.
Coronavirus disease (COVID-19) is an infectious disease caused by a recently discovered coronavirus. Blood test including complete blood count is crucial in diagnosing of several viral and bacterial infection.
This study aimed to assess the association between lymphocyte ratio and other WBC types and severity of COVID-19 pneumonia.
The design of this study was a cross-sectional study. A complete blood count and erythrocyte sedimentation rate (ESR) was done for one hundred twenty-six COVID-19 patients (76 males and 50 females; aged 20-70 years). Patients were randomly recruited from multicenter in Al-Najaf Governorate, Iraq.
The study had revealed an inverse correlation between severity of COVID-19 infection and both lymphocytes and monocytes ratio even in patients with normal WBC count. Additionally, there was a direct correlation between platelets and leukocyte count. The relation between leukocyte count and ESR level was significant in a patient with elevated WBC only.
Lymphocytes and monocyte ratios inpatient with COVID-19 infection can be used as predictors for the severity of infection. Increased leukocyte count resulted in increases in platelets inpatient with COVID-19.
冠状病毒病（COVID-19）是一种由最近发现的冠状病毒引起的传染病。包括全血细胞计数在内的血液检查对于诊断多种病毒和细菌感染至关重要。
本研究旨在评估淋巴细胞比例及其他白细胞类型与COVID-19肺炎严重程度之间的关联。
本研究的设计为横断面研究。对126例COVID-19患者（76例男性和50例女性；年龄20 - 70岁）进行了全血细胞计数和红细胞沉降率（ESR）检测。患者从伊拉克纳杰夫省的多个中心随机招募。
该研究揭示，即使在白细胞计数正常的患者中，COVID-19感染的严重程度与淋巴细胞和单核细胞比例均呈负相关。此外，血小板与白细胞计数之间存在正相关。仅在白细胞升高的患者中，白细胞计数与ESR水平之间的关系显著。
COVID-19感染患者的淋巴细胞和单核细胞比例可作为感染严重程度的预测指标。COVID-19患者白细胞计数增加导致血小板增加。
