Henan Key Laboratory of Medical Tissue Regeneration, Xinxiang Medical University, 601 Jinsui Road, Xinxiang, 453003, Henan, China.
Department of Cardiology, Zhengzhou Seventh People's Hospital, Zhengzhou, China.
Stem Cell Res Ther. 2021 Nov 22;12(1):583. doi: 10.1186/s13287-021-02650-w.
Stem cell therapy is widely recognized as a promising strategy for exerting therapeutic effects after injury in degenerative diseases. However, limitations such as low cell retention and survival rates after transplantation exist in clinical applications. In recent years, emerging biomaterials that provide a supportable cellular microenvironment for transplanted cells have optimized the therapeutic efficacy of stem cells in injured tissues or organs. Advances in the engineered microenvironment are revolutionizing our understanding of stem cell-based therapies by co-transplanting with synthetic and tissue-derived biomaterials, which offer a scaffold for stem cells and propose an unprecedented opportunity to further employ significant influences in tissue repair and regeneration.
干细胞治疗被广泛认为是在退行性疾病损伤后发挥治疗作用的有前途的策略。然而，在临床应用中存在诸如移植后细胞保留率和存活率低等局限性。近年来，新兴的生物材料为移植细胞提供了可支持的细胞微环境，从而优化了干细胞在受伤组织或器官中的治疗效果。工程化微环境的进步正在通过与合成和组织衍生的生物材料共同移植来改变我们对基于干细胞的治疗的理解，为干细胞提供支架，并为进一步利用在组织修复和再生方面的重要影响提供了前所未有的机会。
