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用于治疗心血管疾病的干细胞与生物支架:新见解

Stem cells and bio scaffolds for the treatment of cardiovascular diseases: new insights.

作者信息

Razavi Zahra Sadat, Farokhi Simin, Mahmoudvand Golnaz, Karimi-Rouzbahani Arian, Farasati-Far Bahareh, Tahmasebi-Ghorabi Samaneh, Pazoki-Toroudi Hamidreza, Saadat-Fakhr Masoud, Afkhami Hamed

机构信息

Physiology Research Center, Iran University of Medical Sciences, Tehran, Iran.

Student Research Committee, USERN Office, Lorestan University of Medical Sciences, Khorramabad, Iran.

出版信息

Front Cell Dev Biol. 2024 Dec 12;12:1472103. doi: 10.3389/fcell.2024.1472103. eCollection 2024.

Abstract

Mortality and morbidity from cardiovascular diseases are common worldwide. In order to improve survival and quality of life for this patient population, extensive efforts are being made to establish effective therapeutic modalities. New treatment options are needed, it seems. In addition to treating cardiovascular diseases, cell therapy is one of the most promising medical platforms. One of the most effective therapeutic approaches in this area is stem cell therapy. In stem cell biology, multipotent stem cells and pluripotent stem cells are divided into two types. There is evidence that stem cell therapy could be used as a therapeutic approach for cardiovascular diseases based on multiple lines of evidence. The effectiveness of stem cell therapies in humans has been studied in several clinical trials. In spite of the challenges associated with stem cell therapy, it appears that resolving them may lead to stem cells being used in cardiovascular disease patients. This may be an effective therapeutic approach. By mounting these stem cells on biological scaffolds, their effect can be enhanced.

摘要

心血管疾病导致的死亡率和发病率在全球范围内都很常见。为了提高这类患者群体的生存率和生活质量,人们正在做出广泛努力来建立有效的治疗方法。似乎需要新的治疗选择。除了治疗心血管疾病外,细胞治疗是最有前景的医学平台之一。该领域最有效的治疗方法之一是干细胞治疗。在干细胞生物学中,多能干细胞和全能干细胞分为两类。有多项证据表明,干细胞治疗可作为心血管疾病的一种治疗方法。干细胞治疗在人体中的有效性已在多项临床试验中得到研究。尽管干细胞治疗存在挑战,但解决这些挑战可能会使干细胞应用于心血管疾病患者。这可能是一种有效的治疗方法。通过将这些干细胞附着在生物支架上,可以增强它们的效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e75a/11669526/8d76f814331f/fcell-12-1472103-g001.jpg

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