Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg, Germany.
Department of Behavioral and Molecular Neurobiology, University of Regensburg, Regensburg, Germany; Laboratory of Neuroendocrinology, GIGA Neurosciences, University of Liege, Liege, Belgium.
Trends Neurosci. 2022 Jan;45(1):27-40. doi: 10.1016/j.tins.2021.10.010. Epub 2021 Nov 19.
Social interactions are essential for mammalian life and are regulated by evolutionary conserved neuronal mechanisms. An individual's internal state, experiences, and the nature of the social stimulus are critical for determining apt responses to social situations. The lateral septum (LS) - a structure of the basal forebrain - integrates abundant cortical and subcortical inputs, and projects to multiple downstream regions to generate appropriate behavioral responses. Although incoming cognitive information is indispensable for contextualizing a social stimulus, neuromodulatory information related to the internal state of the organism significantly influences the behavioral outcome as well. This review article provides an overview of the neuroanatomical properties of the LS, and examines its neurochemical (neuropeptidergic and hormonal) signaling, which provide the neuromodulatory information essential for fine-tuning social behavior across the lifespan.
社交互动对哺乳动物的生活至关重要，并且受到进化保守的神经元机制的调节。个体的内部状态、经历和社交刺激的性质对于确定对社交情况的适当反应至关重要。外侧隔核（LS）-基底前脑的结构-整合了丰富的皮质和皮质下输入，并投射到多个下游区域以产生适当的行为反应。尽管传入的认知信息对于使社交刺激情境化是必不可少的，但与生物体内部状态相关的神经调制信息也会显著影响行为结果。本文综述了 LS 的神经解剖学特性，并研究了其神经化学（神经肽和激素）信号，这些信号提供了微调整个生命周期社交行为所必需的神经调制信息。
