Key Laboratory of Molecular Medicine and Biotherapy, School of Life Science, Beijing Institute of Technology, Beijing, 100081, China.
Advanced Innovation Center for Human Brain Protection, Capital Medical University, The National Clinical Research Center for Geriatric Disease, Xuanwu Hospital, Capital Medical University, Beijing, China.
Neurosci Biobehav Rev. 2022 Jan;132:857-869. doi: 10.1016/j.neubiorev.2021.11.009. Epub 2021 Nov 20.
The olfactory dysfunction can signal and act as a potential biomarker of preclinical AD. However, the precise regulatory mechanism of olfactory function on the neural pathogenesis of AD is still unclear. The impairment of neural networks in olfaction system has been shown to be tightly associated with AD. As key brain regions of the olfactory system, the olfactory bulb (OB) and the piriform cortex (PCx) have a profound influence on the olfactory function. Therefore, this review will explore the mechanism of olfactory dysfunction in preclinical AD in the perspective of abnormal neural networks in the OB and PCx and their associated brain regions, especially from two aspects of aberrant oscillations and synaptic plasticity damages, which help better understand the underlying mechanism of olfactory neural network damages related to AD.
嗅觉功能障碍可以作为临床前 AD 的潜在生物标志物发挥作用和信号功能。然而，嗅觉功能对 AD 神经发病机制的确切调节机制仍不清楚。嗅觉系统神经网络的损伤已被证明与 AD 密切相关。作为嗅觉系统的关键脑区，嗅球（OB）和梨状皮层（PCx）对嗅觉功能有深远影响。因此，本综述将从 OB 和 PCx 及其相关脑区异常神经网络的角度探讨临床前 AD 嗅觉功能障碍的机制，特别是从异常震荡和突触可塑性损伤两个方面，帮助更好地理解与 AD 相关的嗅觉神经网络损伤的潜在机制。
