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嗅觉丧失通过微生物群-肠道-脑轴诱导小鼠认知障碍和焦虑行为的可能性。

The potential of olfaction loss to induce cognitive impairment and anxiety behavior in mice via the microbiota-gut-brain axis.

作者信息

Zhao Xiangyu, Xue Chao, Wang Yiming, Liu Xiwei, Li Ran, Yi Xianfeng

机构信息

School of Life Sciences, Qufu Normal University, Qufu, China.

出版信息

Front Microbiol. 2025 Jul 2;16:1595742. doi: 10.3389/fmicb.2025.1595742. eCollection 2025.

DOI:10.3389/fmicb.2025.1595742
PMID:40673140
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12265083/
Abstract

INTRODUCTION

Olfactory dysfunction and cognition decline are frequently observed; however, very little is known about whether olfactory disorders trigger cognitive impairment.

METHODS

Here, we induced olfactory loss in mice and investigated whether and how olfactory loss induces cognitive impairment and anxiety behavior.

RESULTS

Olfactory loss not only causes a significant decrease in food intake and body weight and an increase in O consumption but also induces cognitive impairment and anxiety behavior. Olfactory loss-induced alteration of the gut microbiota is associated with subsequent changes in cecal short-chain fatty acids and serum neurotransmitter levels. Hippocampus proteome and fecal microbial transplantation provide further support for the mechanisms by which olfactory loss triggers cognitive impairment and anxiety behavior via the microbiota-gut-brain axis.

DISCUSSION

Our study is expected to provide some evidence for olfactory dysfunction in triggering cognitive impairment through the microbiota-gut-brain axis.

摘要

引言

嗅觉功能障碍和认知能力下降经常被观察到；然而，关于嗅觉障碍是否会引发认知障碍，我们所知甚少。

方法

在此，我们诱导小鼠嗅觉丧失，并研究嗅觉丧失是否以及如何导致认知障碍和焦虑行为。

结果

嗅觉丧失不仅会导致食物摄入量和体重显著下降以及氧气消耗量增加，还会引发认知障碍和焦虑行为。嗅觉丧失引起的肠道微生物群改变与盲肠短链脂肪酸和血清神经递质水平的后续变化有关。海马蛋白质组和粪便微生物移植为嗅觉丧失通过微生物群-肠道-脑轴引发认知障碍和焦虑行为的机制提供了进一步支持。

讨论

我们的研究有望为嗅觉功能障碍通过微生物群-肠道-脑轴引发认知障碍提供一些证据。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/4930e9ef516c/fmicb-16-1595742-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/433b69a6e16a/fmicb-16-1595742-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/437055f893ff/fmicb-16-1595742-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/b941f326ac08/fmicb-16-1595742-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/90396e1cbc5e/fmicb-16-1595742-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/f95c8d2b9718/fmicb-16-1595742-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/54cab0e1147f/fmicb-16-1595742-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/eed3c40ea7bc/fmicb-16-1595742-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/4930e9ef516c/fmicb-16-1595742-g0008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/433b69a6e16a/fmicb-16-1595742-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/437055f893ff/fmicb-16-1595742-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/b941f326ac08/fmicb-16-1595742-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/90396e1cbc5e/fmicb-16-1595742-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/f95c8d2b9718/fmicb-16-1595742-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/54cab0e1147f/fmicb-16-1595742-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/eed3c40ea7bc/fmicb-16-1595742-g0007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/659e/12265083/4930e9ef516c/fmicb-16-1595742-g0008.jpg

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