Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg; Faculty of Science, Technology and Medicine, University of Luxembourg, 4365 Esch-sur-Alzette, Luxembourg.
Department of Infection and Immunity, Luxembourg Institute of Health, 4354 Esch-sur-Alzette, Luxembourg.
Trends Mol Med. 2022 Jan;28(1):36-50. doi: 10.1016/j.molmed.2021.10.004. Epub 2021 Nov 19.
The prevalence of food allergies has reached epidemic levels but the cause remains largely unknown. We discuss the clinical relevance of the gut mucosal barrier as a site for allergic sensitization to food. In this context, we focus on an important but overlooked part of the mucosal barrier in pathogenesis, the glycoprotein-rich mucus layer, and call attention to both beneficial and detrimental aspects of mucus-gut microbiome interactions. Studying the intricate links between the mucus barrier, the associated bacteria, and the mucosal immune system may advance our understanding of the mechanisms and inform prevention and treatment strategies in food allergy.
食物过敏的患病率已达到流行水平，但病因仍很大程度上未知。我们讨论了肠道黏膜屏障作为食物过敏致敏部位的临床相关性。在这方面，我们专注于黏膜屏障在发病机制中的一个重要但被忽视的部分，即富含糖蛋白的黏液层，并提请注意黏液-肠道微生物组相互作用的有益和有害方面。研究黏液屏障、相关细菌和黏膜免疫系统之间的复杂联系，可能有助于我们理解食物过敏的机制，并为预防和治疗策略提供信息。
