Department of Oral and Maxillofacial Surgery, Balaji Dental and Craniofacial Hospital, Chennai, Tamil Nadu, India.
Indian J Dent Res. 2021 Apr-Jun;32(2):261-263. doi: 10.4103/ijdr.ijdr_562_21.
Sarcoidosis is a multisystemic granulomatous disease of unknown aetiology that usually presents with systemic lesions including the skin. Isolated cutaneous lesions are very rare.
We present a middle-aged female patient, a known systemic lupus erythematosus patient, in remission developing an isolated, single sarcoidosis lesion in the perioral labial mucosa. The lesion was a rapidly growing nodular lesion with a papillary surface near the philtrum of the upper lip.
A biopsy revealed that to be a granulomatous lesion with large multinucleated giant cells. Using a panel of tests, by excluding tuberculosis and establishing the immunoprofile, the diagnosis was established. Although infrequent, perioral and oral lesions may constitute the first signs of systemic sarcoidosis.
OUTCOMES AND TAKE-AWAY LESSONS: For this reason, the oral health care provider needs to be watchful and when there is a suspicion of sarcoidosis, systemic sarcoidosis must be included in the differential diagnosis of oral and perioral granulomatous lesions.
结节病是一种病因不明的多系统肉芽肿性疾病，通常表现为全身病变，包括皮肤。孤立性皮肤病变非常罕见。
我们现介绍一位中年女性患者，她患有已知的系统性红斑狼疮，处于缓解期，在上唇人中附近的唇黏膜出现孤立的、单一的结节病病变。病变是一个快速生长的结节状病变，表面呈乳头状。
活检显示为肉芽肿性病变，有大的多核巨细胞。通过一系列排除结核病和建立免疫表型的检查，做出了诊断。尽管不常见，但口周和口腔病变可能构成系统性结节病的首发征象。
因此，口腔保健提供者需要保持警惕，当怀疑有结节病时，口腔和口周肉芽肿性病变的鉴别诊断中必须包括系统性结节病。
