Hiraizumi Y, Hisamitsu T, Ichikawa S, Fujimaki E
Department of Orthopedics, School of Medicine, Showa University, Tokyo, Japan.
Physiol Behav. 1987;41(4):331-9. doi: 10.1016/0031-9384(87)90397-0.
Neurogenic bladder was observed in chronic spinalized animals. Since these animals are difficult to maintain for long periods, there are few reports of systemic study of these preparations. We have recently observed micturition by spinalized rabbits over a period of 4 weeks. In thoracic or lumbar spinalized rabbits, urinary bladder contraction and external urethral sphincter activity were initially recorded from 1-2 days postoperative. Contraction coincided with appearance of hind-limb spasticity. This micturition was the so-called detrusor-external urethral sphincter dyssynergy with residual urine. In sacral spinalized rabbits, no micturition reflex, external urethral sphincter activity, or hind-limb spasticity were observed and the flaccid state continued for 4 weeks. It is suggested that a segmental micturition reflex pathway exists initially in the rabbit sacral cord, because reappearance of the micturition reflex was extremely quick (1-2 days) compared to that of cats (2-3 weeks). Animal hypnosis enabled immobilization during measurement without anesthetic or decerebration. Chronic spinalized rabbits, which are very intolerant to spinal damage, can be maintained alive by intensive care at and post operation and are useful for systemic study of spinal cord injury.
在慢性脊髓损伤的动物中观察到神经源性膀胱。由于这些动物难以长期饲养，因此关于这些实验动物系统研究的报道很少。我们最近观察了脊髓损伤的兔子4周内的排尿情况。在胸段或腰段脊髓损伤的兔子中，术后1 - 2天开始记录膀胱收缩和尿道外括约肌活动。收缩与后肢痉挛的出现同时发生。这种排尿是所谓的逼尿肌 - 尿道外括约肌协同失调伴残余尿。在骶段脊髓损伤的兔子中，未观察到排尿反射、尿道外括约肌活动或后肢痉挛，且弛缓状态持续了4周。这表明兔子骶段脊髓最初存在节段性排尿反射通路，因为与猫（2 - 3周）相比，排尿反射的再次出现极其迅速（1 - 2天）。动物催眠能够在测量过程中无需麻醉或去大脑即可实现固定。慢性脊髓损伤的兔子对脊髓损伤非常不耐受，通过术后的精心护理可以存活，并且对于脊髓损伤的系统研究很有用。
