Julius Bernstein Institute of Physiology, Martin Luther University Halle-Wittenberg, Halle, Saale, Germany.
Departamento de Ciencias Médicas Básicas and Instituto de Tecnologías Biomédicas, Universidad de La Laguna, La Laguna, Tenerife, Spain.
Br J Pharmacol. 2022 Jul;179(13):3103-3118. doi: 10.1111/bph.15746. Epub 2021 Dec 12.
During the past decades, the mineralocorticoid receptor (MR) has evolved from a much-overlooked member of the steroid hormone receptor family to an important player, not only in volume and electrolyte homeostasis but also in pathological changes occurring in an increasing number of tissues, especially the renal and cardiovascular systems. Simultaneously, a wealth of information about the structure, interaction partners and chromatin requirements for genomic signalling of steroid hormone receptors became available. However, much of the information for the MR has been deduced from studies of other family members and there is still a lack of knowledge about MR-specific features in ligand binding, chromatin remodelling, co-factor interactions and general MR specificity-conferring mechanisms that can completely explain the differences in pathophysiological function between MR and its closest relative, the glucocorticoid receptor. This review aims to give an overview of the current knowledge of MR structure, signalling and co-factors modulating its activity. LINKED ARTICLES: This article is part of a themed issue on Emerging Fields for Therapeutic Targeting of the Aldosterone-Mineralocorticoid Receptor Signaling Pathway. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.13/issuetoc.
在过去的几十年里，盐皮质激素受体（MR）已经从类固醇激素受体家族中一个被忽视的成员发展成为一个重要的角色，不仅在体积和电解质平衡中发挥作用，而且在越来越多的组织中发生的病理变化中发挥作用，特别是在肾脏和心血管系统中。同时，关于类固醇激素受体基因组信号转导的结构、相互作用伙伴和染色质要求的大量信息也已经可用。然而，关于 MR 的信息大部分是从其他家族成员的研究中推断出来的，对于配体结合、染色质重塑、共因子相互作用以及一般的 MR 特异性赋予机制中的 MR 特异性特征仍然缺乏了解，这些机制可以完全解释 MR 和其最接近的亲属糖皮质激素受体在病理生理学功能上的差异。这篇综述旨在概述 MR 结构、信号转导以及调节其活性的共因子的最新知识。相关文章：本文是关于醛固酮-盐皮质激素受体信号通路的治疗靶点新兴领域的专题的一部分。要查看本节中的其他文章，请访问 http://onlinelibrary.wiley.com/doi/10.1111/bph.v179.13/issuetoc.
