Xu Duo, Biswal Mahamaya, Neal Arrmund, Hai Rong
Department of Microbiology and Plant Pathology, University of California-Riverside, Riverside, CA, USA.
Department of Biochemistry, University of California-Riverside, Riverside, CA, USA.
Curr Res Virol Sci. 2021;2:100013. doi: 10.1016/j.crviro.2021.100013. Epub 2021 Nov 18.
The unprecedented Coronavirus pandemic of 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Like other coronaviruses, to establish its infection, SARS-CoV-2 is required to overcome the innate interferon (IFN) response, which is the first line of host defense. SARS-CoV-2 has also developed complex antagonism approaches involving almost all its encoding viral proteins. Here, we summarize our current understanding of these different viral factors and their roles in suppressing IFN responses. Some of them are conserved IFN evasion strategies used by SARS-CoV; others are novel countermeasures only employed by SARS-CoV-2. The filling of gaps in understanding these underlying mechanisms will provide rationale guidance for applying IFN treatment against SARS-CoV-2 infection.
2019年爆发的前所未有的冠状病毒大流行（COVID-19）是由严重急性呼吸综合征冠状病毒2（SARS-CoV-2）引起的。与其他冠状病毒一样，为了建立感染，SARS-CoV-2需要克服先天性干扰素（IFN）反应，这是宿主防御的第一道防线。SARS-CoV-2还开发了涉及几乎所有其编码病毒蛋白的复杂拮抗方法。在这里，我们总结了我们目前对这些不同病毒因子及其在抑制IFN反应中的作用的理解。其中一些是SARS-CoV使用的保守IFN逃避策略；其他一些是SARS-CoV-2仅采用的新对策。填补对这些潜在机制理解上的空白将为应用IFN治疗SARS-CoV-2感染提供合理的指导。
