Department of Nutrition, Food and Exercise Sciences, Florida State University, Tallahassee, FL, 32306, USA.
Department of Nutrition, Georgia State University, Atlanta, GA, 30303, USA.
Food Funct. 2021 Dec 13;12(24):12526-12534. doi: 10.1039/d1fo01555a.
Postmenopausal women experience an increase in bone remodeling with the rate of bone resorption superseding the rate of bone formation. This results in a net bone loss with a subsequent increased risk for osteoporosis and fractures. High blood pressure (BP) has been associated with loss of bone mineral density and increased propensity to fractures. Strawberries are rich in polyphenols, which have been shown to have anti-hypertensive and bone-protective properties. Thus, we examined whether daily intake of strawberries would positively affect biomarkers of bone metabolism in postmenopausal women with pre- and stage 1-hypertension. Participants (age: 59 ± 6 years; body mass index: 31.5 ± 4.1 kg m; systolic BP: 140 ± 13 mmHg) were randomly assigned to consume (1) 50 g of freeze-dried strawberry powder (FDSP), (2) 25 g FDSP + 25 g of placebo powder, or (3) 50 g placebo powder for eight weeks. Results indicate a significant time-by-treatment interaction ( = 0.04) for serum insulin-like growth factor (IGF)-1, a hormone that plays a major role in bone formation. Serum concentrations of bone-specific alkaline phosphatase, a marker of bone formation, and tartrate-resistant acid phosphatase-5b, a specific marker of bone resorption, were not affected by FDSP compared to placebo. Although not statistically significant, after eight weeks, osteocalcin increased in the 50 g FDSP group with a large effect size ( = 0.6) when compared to the placebo-control group. Adiponectin increased by 5% and 6% in the 25 g and 50 g FDSP groups, respectively, while it declined in the placebo-control group by 25% ( = 0.03 for time-by-treatment interaction). Our findings suggest that consumption of 25 g FDSP increases IGF-1 in postmenopausal women with pre- and stage 1-hypertension. However, further studies are needed to assert the effectiveness of a strawberry intervention for bone health.
绝经后妇女的骨重建过程中，破骨作用超过成骨作用，导致净骨丢失，从而增加骨质疏松症和骨折的风险。高血压（BP）与骨矿物质密度降低和骨折发生率增加有关。草莓富含多酚，具有降血压和保护骨骼的特性。因此，我们研究了每日摄入草莓是否会对患有前期和 1 期高血压的绝经后妇女的骨代谢生物标志物产生积极影响。参与者（年龄：59 ± 6 岁；体重指数：31.5 ± 4.1 kg/m；收缩压：140 ± 13 mmHg）被随机分为三组，分别摄入（1）50 g 冻干草莓粉（FDSP）、（2）25 g FDSP+25 g 安慰剂粉，或（3）50 g 安慰剂粉，为期 8 周。结果表明，血清胰岛素样生长因子（IGF）-1存在显著的时间-处理交互作用（ = 0.04），IGF-1 是一种在骨形成中起主要作用的激素。与安慰剂相比，FDSP 对血清骨特异性碱性磷酸酶（一种骨形成标志物）和抗酒石酸酸性磷酸酶-5b（一种特定的骨吸收标志物）的浓度没有影响。虽然没有统计学意义，但 8 周后，与安慰剂对照组相比，50 g FDSP 组的骨钙素增加，效应量较大（ = 0.6）。25 g 和 50 g FDSP 组的脂联素分别增加了 5%和 6%，而安慰剂对照组则下降了 25%（时间-处理交互作用的 = 0.03）。我们的研究结果表明，在患有前期和 1 期高血压的绝经后妇女中，摄入 25 g FDSP 可增加 IGF-1。然而，还需要进一步的研究来确定草莓干预对骨骼健康的有效性。
