State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China.
Department of Teaching and Research, Nanjing Forestry University, Huaian 223003, P. R. China.
Org Biomol Chem. 2021 Dec 8;19(47):10296-10313. doi: 10.1039/d1ob01566d.
Phosphoramide, as an important framework of many biologically active molecules, has attracted widespread attention in recent decades. It is not only widely used in pharmaceuticals because of its excellent biological activities, but it also shows good performance in organic dyes, flame retardants and extractors. Thus, it is of great significance to develop effective and convenient methods for the synthesis of phosphoramides. In this review, the recent advancements made in the synthesis routes and applications of phosphoramides are discussed. The synthetic strategies of phosphoramides can be separated into five categories: phosphorus halides as the substrate, phosphates as the substrate, phosphorus hydrogen as the substrate, azides as the substrate and other methods. The latest examples of these methods are provided and some representative mechanisms are also described.
磷酰胺作为许多生物活性分子的重要骨架，近几十年来引起了广泛关注。它不仅由于其出色的生物活性而在药物领域得到广泛应用，而且在有机染料、阻燃剂和萃取剂方面也表现出良好的性能。因此，开发有效且方便的磷酰胺合成方法具有重要意义。本文综述了磷酰胺的合成路线和应用的最新进展。磷酰胺的合成策略可以分为五类：以卤代磷为底物、以磷酸盐为底物、以磷氢为底物、以叠氮化物为底物和其他方法。提供了这些方法的最新实例，并描述了一些代表性的机制。
