Department of Orthopaedics Surgery, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou 325000, China.
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325015, China.
Molecules. 2023 May 31;28(11):4466. doi: 10.3390/molecules28114466.
Versatile and concise Pd-catalyzed oxidative -alkenylation of -aryl phosphoramidates with alkenes is described in this study, a reaction that is of great significance but surprisingly unexploited. The transformation proceeds under mild reaction conditions, using O as a green oxidant and TBAB as an effective additive. An efficient catalytic system allows a variety of drug-related substrates to participate in these transformations, which is of great interest in the drug discovery and development of phosphoramidates.
本研究中描述了一种多功能且简洁的 Pd 催化的芳基膦酰胺与烯烃的氧化-烯丙基化反应，该反应具有重要意义，但令人惊讶的是尚未得到充分利用。该转化在温和的反应条件下进行，使用 O 作为绿色氧化剂和 TBAB 作为有效添加剂。一个高效的催化体系允许各种与药物相关的底物参与这些转化，这对于药物发现和磷酰胺的开发具有重要意义。
