HLA-DQ1 + DQ3特异性单克隆抗体与大鼠MHC编码的多态性决定簇发生交叉反应。
HLA-DQ1 + DQ3-specific monoclonal antibody cross-reacts with a rat MHC-encoded polymorphic determinant.
作者信息
Otová B, Stefanová I, Horejsí V, Nĕmec M, Kren V, Viklický V
机构信息
Department of Biology, Faculty of Medicine, Charles University, Praha.
出版信息
Folia Biol (Praha). 1987;33(6):424-9.
From a panel of seven mouse monoclonal antibodies against human class II molecules only one, HL-37, directed against the beta chain of human DQ1 and DQ3 antigens cross-reacted in membrane immunofluorescence with the RT1b haplotype of the rat major histocompatibility complex. From the results obtained using an indirect immunoprecipitation method with 35S- and 125I-labelled rat samples from RT1b-carrying lymph node cells it can be supposed that the rat homologue of the human DQ beta chain was detected.
在一组针对人类Ⅱ类分子的七种小鼠单克隆抗体中，只有一种名为HL-37的抗体，它针对人类DQ1和DQ3抗原的β链，在膜免疫荧光检测中与大鼠主要组织相容性复合体的RT1b单倍型发生交叉反应。使用间接免疫沉淀法，对来自携带RT1b的淋巴结细胞的35S和125I标记的大鼠样本进行检测，结果表明可能检测到了人类DQβ链的大鼠同源物。
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