Mauler David J, Sella David M, Dora Chandler D
Mayo Clinic Alix School of Medicine, Rochester, MN.
Department of Radiology, Mayo Clinic Florida, Jacksonville, FL.
Urology. 2022 Feb;160:176-181. doi: 10.1016/j.urology.2021.11.009. Epub 2021 Nov 20.
To determine if transition zone (TZ) volume as measured by magnetic resonance imaging (MRI) correlates closely with specimen weight and postoperative prostate-specific antigen (PSA) and to determine if this correlation improved with increased experience. We hypothesize that information from a preoperative MRI can be leveraged to self-assess competency in holmium laser enucleation of the prostate (HoLEP).
From August 2018 to June 2021 567 men were identified who underwent HoLEP by a single surgeon and had their data entered into a database. Ninety-seven men were identified who had an MRI in our image archives. A radiologist blinded to the specimen weight measured the transition zone (TZ) using image analysis software. TZ volume was then correlated with specimen weight for the entire study period and subdivided into four consecutive periods. Preoperative and Postoperative PSA data was analyzed.
Seventeen percent of men who underwent HoLEP at our institution had an MRI preoperatively. The TZ to total prostate volume ratio was 70%. The overall correlation coefficient between TZ volume and specimen weight was 0.914 (P-value <.001). There was no statistically significant improvement in correlation coefficient over time when divided into four equal subgroups. Median PSA reduction was 91% (7.9-0.7 ng/dL).
Preoperative MRI derived TZ volume correlates closely with specimen weight. We present a reference cohort from a high volume HoLEP center to facilitate HoLEP learners to self-assess competency. Lack of increased correlation over time is likely due to an experienced HoLEP surgeon who is on the flatter portion of his learning curve.
确定通过磁共振成像(MRI)测量的移行区(TZ)体积与标本重量及术后前列腺特异性抗原(PSA)是否密切相关,并确定这种相关性是否会随着经验的增加而改善。我们假设术前MRI的信息可用于自我评估前列腺钬激光剜除术(HoLEP)的操作能力。
2018年8月至2021年6月期间,确定了567名接受同一位外科医生进行HoLEP手术的男性,并将他们的数据录入数据库。在我们的图像档案中确定了97名进行过MRI检查的男性。一名对标本重量不知情的放射科医生使用图像分析软件测量移行区(TZ)。然后在整个研究期间将TZ体积与标本重量进行相关性分析,并细分为四个连续时间段。对术前和术后的PSA数据进行分析。
在我们机构接受HoLEP手术的男性中,17%术前进行了MRI检查。TZ与前列腺总体积之比为70%。TZ体积与标本重量之间的总体相关系数为0.914(P值<.001)。分为四个相等亚组时,相关系数随时间没有统计学上的显著改善。PSA中位数下降了91%(7.9 - 0.7 ng/dL)。
术前MRI得出的TZ体积与标本重量密切相关。我们提供了一个来自高容量HoLEP中心的参考队列,以帮助HoLEP学习者自我评估操作能力。随着时间推移相关性未增加可能是由于一名经验丰富的HoLEP外科医生处于其学习曲线较平缓的阶段。