Biological Psychology, Department of Psychology, School of Medicine and Health Sciences, Carl-von-Ossietzky Universität Oldenburg, Postfach 2503, Oldenburg 26111, Germany; University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, Netherlands.
University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, Netherlands.
Neuroimage. 2021 Dec 15;245:118729. doi: 10.1016/j.neuroimage.2021.118729. Epub 2021 Nov 20.
The course of attention deficit hyperactivity disorder (ADHD) from adolescence into adulthood shows large variations between individuals; nonetheless determinants of interindividual differences in the course are not well understood. A frequent problem in ADHD, associated with worse outcomes, is emotion dysregulation. We investigated whether emotion dysregulation and integration of emotion-related functional brain networks affect interindividual differences in ADHD severity change. ADHD severity and resting state neuroimaging data were measured in ADHD and unaffected individuals at two points during adolescence and young adulthood. Bivariate latent change score models were applied to investigate whether emotion dysregulation and network integration affect ADHD severity changes. Emotion dysregulation was gauged from questionnaire subscales for conduct problems, emotional problems and emotional lability. Better emotion regulation was associated with a better course of ADHD (104 participants, 44 females, age range: 12-27). Using graph analysis, we determined network integration of emotion-related functional brain networks. Network integration was measured by nodal efficiency, i.e., the average inverse path distance from one node to all other nodes. A pattern of low nodal efficiency of cortical regions associated with emotion processing and high nodal efficiency in subcortical areas and cortical areas involved in implicit emotion regulation predicted a better ADHD course. Larger nodal efficiency of the right orbitofrontal cortex was related to a better course of ADHD (99 participants, 42 females, age range: 10-29). We demonstrated that neural and behavioral covariates associated with emotion regulation affect the course of ADHD severity throughout adolescence and early adulthood beyond baseline effects of ADHD severity.
注意缺陷多动障碍（ADHD）从青春期到成年的病程在个体之间存在很大差异；然而，病程中个体差异的决定因素尚不清楚。ADHD 的一个常见问题是情绪调节障碍，这与更糟糕的结果相关。我们研究了情绪调节障碍和情绪相关功能脑网络的整合是否会影响 ADHD 严重程度变化的个体差异。在青春期和成年早期的两个时间点，对 ADHD 患者和未受影响者的 ADHD 严重程度和静息状态神经影像学数据进行了测量。采用双变量潜变量变化得分模型来研究情绪调节障碍和网络整合是否会影响 ADHD 严重程度的变化。情绪调节障碍通过问卷亚量表评估，用于评估行为问题、情绪问题和情绪不稳定性。更好的情绪调节与 ADHD 病程的改善相关（104 名参与者，44 名女性，年龄范围：12-27 岁）。使用图分析确定情绪相关功能脑网络的网络整合。网络整合通过节点效率来衡量，即从一个节点到所有其他节点的平均逆路径距离。与情绪处理相关的皮质区域的节点效率低，与内隐情绪调节相关的皮质下区域和皮质区域的节点效率高的模式预测了更好的 ADHD 病程。右侧眶额皮层的节点效率较大与 ADHD 病程的改善相关（99 名参与者，42 名女性，年龄范围：10-29 岁）。我们证明了与情绪调节相关的神经和行为协变量会影响 ADHD 严重程度的病程，这超出了 ADHD 严重程度的基线效应。
