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转化生长因子β（TGF-β）对分离肝细胞中ATP柠檬酸裂解酶的影响。

Effect of transforming growth factor beta (TGF-beta) on ATP citrate lyase in isolated hepatocytes.

作者信息

Reinhart G, Roehrig K

机构信息

Department of Food Science and Nutrition, Ohio State University, Columbus 43210.

出版信息

Mol Cell Biochem. 1987 Oct;77(2):121-5. doi: 10.1007/BF00221920.

DOI:10.1007/BF00221920
PMID:3481431
Abstract

Transforming growth factor beta (TGF-beta) activates ATP citrate lyase in freshly isolated rat liver hepatocytes in a time dependent manner. Maximal stimulation of the enzyme occurred with less than thirty minutes of incubation of the cells with TGF-beta. The half-maximal effect on the enzyme determined in hepatocytes incubated with TGF-beta for 10 min at 37 degrees C was elicited by TGF-beta concentrations in the 10-11 - 10-12 M range. The potential role of TGF-beta stimulation of ATP citrate lyase activity in new membrane synthesis is discussed.

摘要

转化生长因子β（TGF-β）能以时间依赖性方式激活新鲜分离的大鼠肝脏肝细胞中的ATP柠檬酸裂解酶。用TGF-β孵育细胞不到30分钟时，该酶受到最大程度的刺激。在37℃下用TGF-β孵育肝细胞10分钟后，TGF-β浓度在10⁻¹¹ - 10⁻¹² M范围内可引发对该酶的半数最大效应。本文讨论了TGF-β刺激ATP柠檬酸裂解酶活性在新膜合成中的潜在作用。

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Effect of transforming growth factor beta (TGF-beta) on ATP citrate lyase in isolated hepatocytes.转化生长因子β（TGF-β）对分离肝细胞中ATP柠檬酸裂解酶的影响。
Mol Cell Biochem. 1987 Oct;77(2):121-5. doi: 10.1007/BF00221920.
2
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本文引用的文献

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Association of ATP citrate lyase with mitochondria.ATP柠檬酸裂解酶与线粒体的关联。
Biochem Biophys Res Commun. 1980 Jan 15;92(1):305-12. doi: 10.1016/0006-291x(80)91553-3.
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Effect of dietary state on hepatocyte size.饮食状态对肝细胞大小的影响。
Biosci Rep. 1982 Dec;2(12):1003-7. doi: 10.1007/BF01122168.
3
Stimulatin of phospholipid and cholesterol ester synthesis by platelet-derived growth factor in normal and homozygous familial hypercholesterolemia human skin fibroblasts.血小板衍生生长因子对正常及纯合子家族性高胆固醇血症人皮肤成纤维细胞中磷脂和胆固醇酯合成的刺激作用
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New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.由表皮生长因子增强的新型转化生长因子：从非肿瘤组织中分离得到。
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Inhibition by bacitracin of rat adipocyte plasma membrane degradation of 125I-insulin is associated with an increase in plasma membrane bound insulin and a potentiation of glucose oxidation by adipocytes.杆菌肽对大鼠脂肪细胞质膜降解¹²⁵I-胰岛素的抑制作用与质膜结合胰岛素的增加以及脂肪细胞葡萄糖氧化的增强有关。
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Glucose- and insulin-independent induction of ATP citrate lyase in primary cultures of rat hepatocytes.大鼠肝细胞原代培养物中ATP柠檬酸裂解酶的葡萄糖和胰岛素非依赖性诱导
Biochem J. 1983 Apr 15;212(1):65-71. doi: 10.1042/bj2120065.
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Transforming growth factors from neoplastic and nonneoplastic tissues.来自肿瘤组织和非肿瘤组织的转化生长因子。
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Induction of lipogenic enzymes in primary cultures of rat hepatocytes. Relationship between lipogenesis and carbohydrate metabolism.大鼠肝细胞原代培养中脂肪生成酶的诱导。脂肪生成与碳水化合物代谢之间的关系。
Eur J Biochem. 1982 Nov;128(1):15-20. doi: 10.1111/j.1432-1033.1982.tb06924.x.
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Stoichiometry of phosphorylation of hepatic ATP-citrate lyase by protein kinase.蛋白激酶对肝脏ATP-柠檬酸裂解酶磷酸化的化学计量学
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