Xin P, Jiang G H, Zheng W L, Fan L L, Li C K, Wang D Z
Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Jul 10;42(7):1213-1217. doi: 10.3760/cma.j.cn112338-20200831-01112.
To understand the influence of birth weight on the risk of chronic diseases, such as hypertension and diabetes, and the relationship between birth weight and serum uric acid in adulthood. According to the Chinese Adult Chronic Disease and Nutrition Surveillance Program, a total of 1 131 residents aged 18 years and above were enrolled from Hexi, Nankai, Hongqiao, Wuqing, Jinnan, Baodi and Jizhou districts of Tianjin. The data of birth weight and blood pressure of the residents were collected, and fasting venous blood samples were collected from them to detect uric acid, blood glucose and blood lipids levels. The distribution of birth weight of the surveyed population was described, and the relationship between birth weight and chronic diseases, such as hypertension and diabetes, and the blood uric acid level in adulthood were analyzed. The average birth weight of the surveyed population in Tianjin was 3.37 kg, which was higher in males than in females. No matter overweight/obesity, hypertension or diabetes, the prevalence rate of normal birth weight was the lowest in adulthood. After univariate logistic regression analysis and adjusting for age, sex, smoking and drinking status, it was found that compared with normal birth weight, low birth weight had a stronger correlation with diabetes (=2.91,95%:1.46-5.76) and dyslipidemia (=1.79,95%:1.01-3.19) in adulthood. Macrosomia was strongly associated with overweight/obesity in adulthood (=1.47, 95%:1.08-2.01). There was no significant difference in serum uric acid level among the residents with different birth weights. The low birth weight of the surveyed population in Tianjin was closely related to the risk of diabetes and dyslipidemia in adulthood, and the macrosomia was closely related to the risk of overweight/obesity in adulthood.
为了解出生体重对高血压、糖尿病等慢性疾病风险的影响，以及成年期出生体重与血清尿酸之间的关系。根据中国成人慢性病与营养监测项目，从天津市河西区、南开区、红桥区、武清区、津南区、宝坻区和蓟州区共纳入1131名18岁及以上居民。收集居民的出生体重和血压数据，并采集其空腹静脉血样本检测尿酸、血糖和血脂水平。描述了被调查人群的出生体重分布情况，并分析了出生体重与高血压、糖尿病等慢性疾病以及成年期血尿酸水平之间的关系。天津市被调查人群的平均出生体重为3.37kg，男性高于女性。无论超重/肥胖、高血压还是糖尿病，成年期正常出生体重的患病率最低。经单因素logistic回归分析并调整年龄、性别、吸烟和饮酒状况后，发现与正常出生体重相比，低出生体重在成年期与糖尿病（=2.91，95%：1.46 - 5.76）和血脂异常（=1.79，95%：1.01 - 3.19）的相关性更强。巨大儿在成年期与超重/肥胖密切相关（=1.47，95%：1.08 - 2.01）。不同出生体重的居民血清尿酸水平无显著差异。天津市被调查人群的低出生体重与成年期糖尿病和血脂异常风险密切相关，巨大儿与成年期超重/肥胖风险密切相关。
