Xie Z Y, Cao G, Kong C, Chen J J, Wang T, Zheng S, Li B X, Li Y X, Zu W L, Ye H F
Population and Family Planning Institute of Yunnan Province, Key Laboratory of Fertility Regulation and Minority Birth Health Research of Yunnan Province, Key Laboratory of Preconception Health in Western China of National Health Commission, Kunming 650021, China.
Key Laboratory of Medicinal Chemistry for Natural Resource (Yunnan University), Ministry of Education,Yunnan Provincial Center for Research & Development of Natural Products, Kunming 650091, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Aug 10;42(8):1475-1481. doi: 10.3760/cma.j.cn112338-20210203-00091.
To determine the prevalence, epidemiological characteristics, and related factors of syphilis infection among rural childbearing age people to promote medical interventions on pre-pregnancy aristogenesis and syphilis infection in Yunnan province. The subjects in this study were 18-49-year-old rural couples of childbearing age from the National Free Preconception Health Examination Project in Yunnan province during 2013-2017. The descriptive study was carried out to determine the positive rate of specific antibody (TPsAb) and related sociodemographic characteristics. The overall positive rate of TPsAb was 0.38% (8 204/2 160 455) in 2 160 455 rural childbearing age people in Yunnan. The positive rate of TPsAb was 0.39% (4 019/1 040 981) in men,higher than that in women (0.37%,4 185/1 119 474). The positive rate of TPsAb was highest in the age group 45-49 years (0.70%,158/22 511). The positive rate of TP antibody in the minority ethnic groups and Han ethnic groups appeared the same (0.38%). However,the highest positive rate of TPsAb was 0.77% (461/60 153) in Hani ethnic group among all the 17 minority ethnic groups. People with education level of primary education had the highest anti-TP positive rate (0.54%,2 327/431 275). The positive rate of TPsAb appeared the highest in Zhaotong (0.73%, 2 049/281 614) area among all the 16 prefectures of the province. The positive rate of TPsAb in the population from the impoverished regions (0.50%,2 963/590 039) was higher than in other disadvantaged areas (0.34%, 3 115/929 368) or areas with average income (0.33%,2 126/641 048). Significant differences appeared in the positive rate of TPsAb among populations of different ages, ethnic, education level, and economic level groups (trend test, <0.001). The positive rate of TP antibody in rural childbearing age people in Yunnan was related to multi factors,including sex,age,ethnic group,education level,area, residence, and local economic situation. The positive rate of TPsAb was higher in men than in women. And people with elder age, lower education level, being Hani or Lahu ethnic group, and Zhaotong areas had higher TPsAb positive rates and higher syphilis infection risk.
为确定云南省农村育龄人群梅毒感染的患病率、流行病学特征及相关因素，以推动孕前优生和梅毒感染的医学干预。本研究的对象是2013 - 2017年云南省国家免费孕前优生健康检查项目中的18 - 49岁农村育龄夫妇。开展描述性研究以确定特异性抗体（TPsAb）的阳性率及相关社会人口学特征。云南省2160455名农村育龄人群中TPsAb总体阳性率为0.38%（8204/2160455）。男性TPsAb阳性率为0.39%（4019/1040981），高于女性（0.37%，4185/1119474）。TPsAb阳性率在45 - 49岁年龄组最高（0.70%，158/22511）。少数民族和汉族的TP抗体阳性率相同（0.38%）。然而，在所有17个少数民族中，哈尼族的TPsAb阳性率最高，为0.77%（461/60153）。小学文化程度人群的抗TP阳性率最高（0.54%，2327/431275）。在全省16个州中，昭通地区的TPsAb阳性率最高（0.73%，2049/281614）。贫困地区人群的TPsAb阳性率（0.50%，2963/590039）高于其他贫困地区（0.34%，3115/929368）或中等收入地区（0.33%，2126/641048）。不同年龄、民族、文化程度和经济水平组人群的TPsAb阳性率存在显著差异（趋势检验，<0.001）。云南省农村育龄人群的TP抗体阳性率与多种因素有关，包括性别、年龄、民族、文化程度、地区、居住地和当地经济状况。男性的TPsAb阳性率高于女性。年龄较大、文化程度较低、哈尼族或拉祜族以及昭通地区的人群TPsAb阳性率较高，梅毒感染风险也较高。
