Li D F, Chen H C, Jin X M, Dai J, Zeng Z J, Yang M, Sun P Y, Dong L J, Han Y, Ma Y L, Chen M, Song Z Z
School of Public Health, Kunming Medical University, Kunming 650500, China.
Institute for AIDS/STD Prevention and Control, Yunnan Center for Disease Control and Prevention, Kunming 650022, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Nov 10;42(11):1983-1988. doi: 10.3760/cma.j.cn112338-20210517-00406.
To understand the infection status of HCV and (TP) in HIV/AIDS cases in Yunnan province,and identify the risk factors. Between January 1 and June 30 in 2020,a cross-sectional survey was conducted in Yunnan. Two enzyme-linked immunosorbent assay (ELISA) kits were used to detect anti-HCV, the positive results of both two kits indicated HCV infection. ELISA and syphilis toluidine red untreated serum test were applied to identify TP infection. Both Excel 2016 and SPSS 22.0 software were used for statistical analysis, and logistic regression model was conducted to identify the relevant factors of HCV and TP infection. A total of 5 922 HIV/AIDS cases were included in this study, the infection rates of HCV and TP were 6.5% (383/5 922) and 5.8% (344/5 922) respectively. The co-infection rate of HCV and TP was 0.4% (22/5 922). The risk for HCV infection in HIV/AIDS cases was higher in younger age groups compared with age group ≥50 years (15-19:a=3.53;20-29:a=3.02;30-39:a=2.91;40-49:a=3.61), in males than in females (a=2.31), in the married and unmarried than in the divorced or widowed (married:a=1.61;unmarried:a=1.63), in other ethnic groups than in Han ethnic group (a=1.70), in people with lower education level than in people with education level of college and above (primary school degree and below:a=4.69;middle school:a=3.96), in people living in the central and western Yunnan than in people living in eastern Yunnan (central Yunnan:a=2.46; western Yunnan:a=7.08), in injection drug users than in MSM (a=131.08). The risk of TP infection in HIV/AIDS cases was higher in people with education level of college and primary school than in middle school degree (primary school and below:a=1.73;college and above:a=1.77), in people with other occupations than in farmers (a=1.39), in people living in eastern Yunnan than in people living in western Yunnan (a=1.75); in MSM than in people with heterosex (a=9.75). A certain proportion of HIV/AIDS cases reported between January and June in 2020 in Yunnan were co-infected with HCV and TP, many factors were associated with the co-infection. It is suggested to strengthen HCV and TP tests in HIV/AIDS cases and conduct active treatment of the co-infection.
了解云南省艾滋病病毒/艾滋病（HIV/AIDS）患者丙型肝炎病毒（HCV）和梅毒螺旋体（TP）的感染状况，并识别相关危险因素。于2020年1月1日至6月30日在云南省开展了一项横断面调查。使用两种酶联免疫吸附试验（ELISA）试剂盒检测抗HCV，两种试剂盒检测结果均为阳性则表明存在HCV感染。采用ELISA和梅毒甲苯胺红不加热血清试验来确定TP感染情况。运用Excel 2016和SPSS 22.0软件进行统计分析，并采用逻辑回归模型识别HCV和TP感染的相关因素。本研究共纳入5922例HIV/AIDS患者，HCV和TP的感染率分别为6.5%（383/5922）和5.8%（344/5922）。HCV和TP的合并感染率为0.4%（22/5922）。与≥50岁年龄组相比，HIV/AIDS患者中年龄较小的组HCV感染风险更高（15 - 19岁：a = 3.53；20 - 29岁：a = 3.02；30 - 39岁：a = 2.91；40 - 49岁：a = 3.61），男性高于女性（a = 2.31），已婚和未婚者高于离异或丧偶者（已婚：a = 1.61；未婚：a = 1.63），其他民族高于汉族（a = 1.70），文化程度较低者高于大专及以上文化程度者（小学及以下学历：a = 4.69；中学：a = 3.96），居住在云南中部和西部的人高于居住在云南东部的人（云南中部：a = 2.46；云南西部：a = 7.08），注射吸毒者高于男男性行为者（a = 131.08）。HIV/AIDS患者中，文化程度为小学及大专的人TP感染风险高于中学学历者（小学及以下学历：a = 1.73；大专及以上学历：a = 1.77），其他职业者高于农民（a = 1.39），居住在云南东部的人高于居住在云南西部的人（a = 1.75）；男男性行为者高于异性性行为者（a = 9.75）。2020年1月至6月间报告的云南省部分HIV/AIDS患者合并感染了HCV和TP，多种因素与合并感染有关。建议加强对HIV/AIDS患者的HCV和TP检测，并对合并感染进行积极治疗。
