Jing H, Li J, Du Y J, Teng Y X, Qu P F, Zhang R, Yang J M, Dang S N
Department of Epidemiology and Biostatistics, School of Public Health, Xi'an Jiaotong University Health Science Center, Xi'an 710061, China.
Assisted Reproduction Center, Northwest Women's and Children's Hospital, Xi'an Jiaotong University, Xi'an 710003, China.
Zhonghua Liu Xing Bing Xue Za Zhi. 2021 Sep 10;42(9):1635-1640. doi: 10.3760/cma.j.cn112338-20201103-01301.
To explore the association of maternal anxiety with congenital heart disease (CHD) in offspring. A case-control study design was used in this study. The data were collected in Shaanxi province from January 2014 to December 2016. Neonatal information is provided through specialized hospitals or institutions. Logistic regression model with adjustment for confounding factors was established to analyze the association between maternal perinatal anxiety and CHD in offspring. Meanwhile, subgroup analysis was carried out to explore its stability. Our study included 2 429 subjects, consisting of 773 cases and 1 656 controls. Women with anxiety during pregnancy accounted for 10.3% in the case group, while 7.8% in the control group. After adjusting for confounding factors, the level of maternal anxiety during pregnancy was positively correlated with CHD in the offspring (=1.04, 95%: 1.01-1.07). The risk of CHD in the offspring of mothers with anxiety during pregnancy was 1.43 times higher than that in those whose mothers had no anxiety (=1.43, 95%: 1.00-2.05). Maternal anxiety during pregnancy is probably a risk factor for congenital heart disease in offspring.
为探讨母亲焦虑与子代先天性心脏病（CHD）之间的关联。本研究采用病例对照研究设计。数据于2014年1月至2016年12月在陕西省收集。新生儿信息通过专科医院或机构提供。建立了调整混杂因素的逻辑回归模型，以分析母亲围产期焦虑与子代CHD之间的关联。同时，进行亚组分析以探讨其稳定性。我们的研究纳入了2429名受试者，包括773例病例和1656例对照。病例组中孕期焦虑的女性占10.3%，而对照组中为7.8%。调整混杂因素后，孕期母亲焦虑水平与子代CHD呈正相关（=1.04，95%：1.01 - 1.07）。孕期焦虑母亲的子代患CHD的风险比母亲无焦虑的子代高1.43倍（=1.43，95%：1.00 - 2.05）。孕期母亲焦虑可能是子代先天性心脏病的一个危险因素。
