运动模拟物及其天然激活剂的分子靶标。
Molecular targets of exercise mimetics and their natural activators.
机构信息
Major of Food Science & Technology, Seoul Women's University, Seoul 01797, Korea.
Department of Biotechnology, College of Life Science and Biotechnology, Yonsei University, Seoul 03722, Korea.
出版信息
BMB Rep. 2021 Dec;54(12):581-591. doi: 10.5483/BMBRep.2021.54.12.151.
Physical exercise can be effective in preventing or ameliorating various diseases, including diabetes, cardiovascular diseases, neurodegenerative diseases, and cancer. However, not everyone may be able to participate in exercise due to illnesses, age-related frailty, or difficulty in long-term behavior change. An alternative option is to utilize pharmacological interventions that mimic the positive effects of exercise training. Recent studies have identified signaling pathways associated with the benefits of physical activity and discovered exercise mimetics that can partially simulate the systemic impact of exercise. This review describes the molecular targets for exercise mimetics and their effect on skeletal muscle and other tissues. We will also discuss the potential advantages of using natural products as a multitargeting agent for mimicking the health-promoting effects of exercise. [BMB Reports 2021; 54(12): 581-591].
体育锻炼可以有效预防或改善多种疾病，包括糖尿病、心血管疾病、神经退行性疾病和癌症。然而，由于疾病、与年龄相关的虚弱或长期行为改变的困难，并非每个人都能够参加锻炼。另一种选择是利用药理学干预措施来模拟运动训练的积极效果。最近的研究已经确定了与身体活动益处相关的信号通路，并发现了可以部分模拟运动对全身影响的运动模拟物。这篇综述描述了运动模拟物的分子靶点及其对骨骼肌和其他组织的影响。我们还将讨论使用天然产物作为模拟运动促进健康作用的多靶点药物的潜在优势。[BMB 报告 2021；54(12)：581-591]。
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