鉴定脆弱马尾藻提取物的成分及其对肌肉重量和运动耐力的影响。

Identifying Codium fragile extract components and their effects on muscle weight and exercise endurance.

机构信息

Natural Materials and Metabolism Research Group, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea; Department of Food Science and Technology, Chonbuk National University, Jeonju-si 54896, Republic of Korea.

Healthcare Research Group, Korea Food Research Institute, Wanju-gun 55365, Republic of Korea.

出版信息

Food Chem. 2021 Aug 15;353:129463. doi: 10.1016/j.foodchem.2021.129463. Epub 2021 Mar 7.

DOI:10.1016/j.foodchem.2021.129463

PMID:33743428

Abstract

Codium fragile (CF) is a type of green algae consumed as kimchi in Asia. UPLC-QTOF-MS/MS analysis showed that CF contain lysophosphatidyl choline, canthaxanthin, retinoic acid, α-tocopherol, and unsaturated fatty acids, which reportedly improve skeletal muscle health. However, the effect of CF on skeletal muscle mass and function remains to be elucidated. In mice fed with CF extracts, exercise endurance and muscle weight increased. CF extracts enhanced protein synthesis and myogenic differentiation through the mTORC1 pathway. CF extracts also promoted oxidative muscle fiber formation and mitochondrial biogenesis through the PGC-1α-related signaling pathway. Upregulation of PGC-1α by CF extracts was abolished by EX527 SIRT1 inhibitor treatment. Changed signaling molecules in the CF extracts were partially regulated by canthaxanthin, a new compound in CF extracts, suggesting that canthaxanthin contribute synergistically to the effect of CF extracts. Therefore, CF is a potential food source for sport nutrition or prevention of sarcopenia.

摘要

脆江蓠（CF）是一种在亚洲被用作泡菜的绿藻。UPLC-QTOF-MS/MS 分析表明，CF 含有溶血磷脂酰胆碱、角黄素、视黄酸、α-生育酚和不饱和脂肪酸，据报道这些物质可以改善骨骼肌健康。然而，CF 对骨骼肌质量和功能的影响仍有待阐明。在喂食 CF 提取物的小鼠中，运动耐力和肌肉重量增加。CF 提取物通过 mTORC1 通路增强蛋白质合成和成肌分化。CF 提取物还通过 PGC-1α 相关信号通路促进氧化肌纤维形成和线粒体生物发生。CF 提取物对 PGC-1α 的上调作用被 SIRT1 抑制剂 EX527 所消除。CF 提取物中变化的信号分子部分受到 CF 提取物中新化合物角黄素的调节，这表明角黄素对 CF 提取物的作用有协同作用。因此，CF 是运动营养或预防肌肉减少症的潜在食物来源。