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膀胱移行细胞癌行膀胱内卡介苗治疗后发生真菌性主动脉瘤形成。

Mycotic aortic aneurysm formation following intravesical BCG treatment for transitional cell carcinoma of the bladder.

机构信息

Vascular Surgery Department, Sunshine Coast Hospital and Health Service, Birtinya, Queensland, Australia

Infectious Diseases Department, Sunshine Coast Hospital and Health Service, Birtinya, Queensland, Australia.

出版信息

BMJ Case Rep. 2021 Nov 23;14(11):e246389. doi: 10.1136/bcr-2021-246389.

DOI:10.1136/bcr-2021-246389
PMID:34815228
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8611418/
Abstract

Mycotic aneurysms are rare and if left untreated, can have devastating outcomes. In this case, a 72-year-old man presented to hospital with fevers, night sweats and abdominal pain. A CT scan revealed the development an infrarenal pseudoaneurysm over the course of 8 weeks, increasing from 2.8 cm to a 3.1 cm. The aneurysm was not present on a CT scan performed 6 months earlier. The patient underwent an emergency endovascular repair of the aortic aneurysm (EVAR) and was placed on broad-spectrum antibiotics. Intra-aortic blood cultures aspirated adjacent to the aneurysm and tissue biopsy confirmed tuberculosis bovis as the cause of the mycotic aneurysm. The patient had been treated with intravesical BCG for transitional cell carcinoma of the bladder several months prior. The patient was treated with an extended course of antituberculosis medication. He recovered well and was back to his baseline function within weeks.

摘要

真菌性动脉瘤罕见,如果不治疗,可能会产生毁灭性的后果。本例中,一名 72 岁男性因发热、盗汗和腹痛就诊于医院。CT 扫描显示在 8 周内出现了肾下假性动脉瘤,从 2.8 厘米增大至 3.1 厘米。该动脉瘤在 6 个月前进行的 CT 扫描中并未显示。患者接受了紧急腹主动脉瘤腔内修复术(EVAR),并使用了广谱抗生素。在紧邻动脉瘤处抽取了主动脉内血液培养物和组织活检,证实分枝杆菌性真菌性动脉瘤的病因是牛分枝杆菌。患者在几个月前因膀胱移行细胞癌接受了膀胱内卡介苗治疗。患者接受了延长的抗结核药物治疗。他在数周内恢复良好,恢复到基线功能。

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J Vasc Surg Cases Innov Tech. 2023 May 16;9(3):101213. doi: 10.1016/j.jvscit.2023.101213. eCollection 2023 Sep.
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Failed endovascular abdominal aortic aneurysm repair due to infection following intravesical bacillus Calmette-Guérin therapy.卡介苗膀胱内灌注治疗后感染导致血管内腹主动脉瘤修复失败。
J Vasc Surg Cases Innov Tech. 2022 Nov 8;8(4):807-812. doi: 10.1016/j.jvscit.2022.10.020. eCollection 2022 Dec.

本文引用的文献

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Mycobacterium bovis-induced Aneurysm after Intravesical Bacillus Calmette-Guérin Therapy: A Case Study and Literature Review.卡介苗膀胱内灌注治疗后牛分枝杆菌诱发的动脉瘤:病例报告及文献综述
Intern Med. 2018 Feb 1;57(3):429-435. doi: 10.2169/internalmedicine.9102-17. Epub 2017 Nov 1.
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Intravesical Therapy for the Treatment of Nonmuscle Invasive Bladder Cancer: A Systematic Review and Meta-Analysis.经尿道治疗非肌肉浸润性膀胱癌:系统评价和荟萃分析。
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Complications of intravesical bacillus calmette-guérin.膀胱内卡介苗接种的并发症
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Primary infected abdominal aortic aneurysm: surgical procedures, early mortality rates, and a survey of the prevalence of infectious organisms over a 30-year period.原发性感染性腹主动脉瘤:30 年来的手术治疗、早期死亡率及感染病原体的流行情况调查。
Surg Today. 2011 Mar;41(3):346-51. doi: 10.1007/s00595-010-4279-z. Epub 2011 Mar 2.
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Intravesical bacillus Calmette-Guerin reduces the risk of progression in patients with superficial bladder cancer: a meta-analysis of the published results of randomized clinical trials.膀胱内灌注卡介苗可降低浅表性膀胱癌患者的疾病进展风险:一项对已发表的随机临床试验结果的荟萃分析。
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Surgical treatment of infected aortic aneurysm.感染性主动脉瘤的外科治疗。
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Ruptured mycotic aneurysm of the abdominal aorta: a serious complication of intravesical instillation bacillus Calmette-Guerin therapy.
J Urol. 1998 Mar;159(3):984. doi: 10.1016/s0022-5347(01)63796-0.
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Infected aortic aneurysm and vertebral osteomyelitis after intravesical bacillus Calmette-Guérin therapy.膀胱内卡介苗治疗后发生感染性主动脉瘤和椎体骨髓炎。
AJR Am J Roentgenol. 1996 Sep;167(3):711-3. doi: 10.2214/ajr.167.3.8751686.
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Mycotic aneurysm. New concepts in therapy.真菌性动脉瘤。治疗的新概念。
Arch Surg. 1983 May;118(5):577-82. doi: 10.1001/archsurg.1983.01390050053010.