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膀胱内卡介苗接种的并发症

Complications of intravesical bacillus calmette-guérin.

作者信息

Macleod Liam C, Ngo Tin C, Gonzalgo Mark L

机构信息

University of Washington School of Medicine, Seattle, WA;

Stanford University School of Medicine, Stanford, CA.

出版信息

Can Urol Assoc J. 2014 Jul;8(7-8):E540-4. doi: 10.5489/cuaj.1411.

DOI:10.5489/cuaj.1411
PMID:25210559
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4137021/
Abstract

Intravesical Bacillus Calmette-Guérin (BCG) is an important treatment for the management of non-muscle invasive bladder cancer because of its proven efficacy and favourable safety profile. The most common complications associated with BCG treatment are relatively minor. They include urinary frequency, cystitis, fever, and hematuria. Although serious complications are rare, patients can develop severe, life-threatening sepsis with disseminated mycobacterial infection. We report a rare case of periurethral diverticulum formation after intravesical BCG and review the literature on the potential complications of this treatment modality.

摘要

膀胱内灌注卡介苗(BCG)是治疗非肌层浸润性膀胱癌的重要方法,因其疗效已得到证实且安全性良好。与卡介苗治疗相关的最常见并发症相对较轻,包括尿频、膀胱炎、发热和血尿。虽然严重并发症罕见,但患者可能会发生严重的、危及生命的播散性分枝杆菌感染败血症。我们报告1例膀胱内灌注卡介苗后发生尿道周围憩室形成的罕见病例,并复习有关这种治疗方式潜在并发症的文献。

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本文引用的文献

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The role of neutrophils and TNF-related apoptosis-inducing ligand (TRAIL) in bacillus Calmette-Guérin (BCG) immunotherapy for urothelial carcinoma of the bladder.中性粒细胞和 TNF 相关凋亡诱导配体 (TRAIL) 在卡介苗(BCG)免疫治疗膀胱尿路上皮癌中的作用。
Cancer Metastasis Rev. 2009 Dec;28(3-4):345-53. doi: 10.1007/s10555-009-9195-6.
2
Cutaneous BCG of the penis after intravesical therapy for bladder cancer: a case report in a 66-year-old male.
Can J Urol. 2009 Oct;16(5):4866-9.
3
Incidental detection of granulomatous prostatitis by F-18 FDG PET/CT in a patient with bladder cancer: a rare complication of BCG instillation therapy.F-18 FDG PET/CT偶然发现膀胱癌患者并发肉芽肿性前列腺炎:卡介苗膀胱灌注治疗的罕见并发症
Clin Nucl Med. 2009 Sep;34(9):613-4. doi: 10.1097/RLU.0b013e3181b06c89.
4
Granulomatous epididymo-orchitis, a rare complication of intravesical bacillus Calmette-Guérin therapy for urothelial cancer.肉芽肿性附睾睾丸炎,是卡介苗膀胱内灌注治疗尿路上皮癌的一种罕见并发症。
Scand J Urol Nephrol. 2009;43(4):331-3. doi: 10.1080/00365590902930808.
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Tuberculous epididymitis following intravesical Bacillus Calmette-Guérin immunotherapy.膀胱内卡介苗免疫治疗后发生的结核性附睾炎。
Can J Urol. 2009 Apr;16(2):4589-91.
6
Is remitting seronegative symmetrical synovitis with pitting edema (RS3PE) a subset of rheumatoid arthritis?缓解型血清阴性对称性滑膜炎伴凹陷性水肿(RS3PE)是否为类风湿关节炎的一个亚型?
Semin Arthritis Rheum. 2010 Aug;40(1):89-94. doi: 10.1016/j.semarthrit.2008.11.006. Epub 2009 Feb 13.
7
[BCG infection of the glans penis after intravesical BCG therapy].[膀胱内卡介苗灌注治疗后阴茎头卡介苗感染]
Ann Dermatol Venereol. 2008 Jun-Jul;135(6-7):479-83. doi: 10.1016/j.annder.2007.06.012. Epub 2008 Mar 20.
8
Management of hepatic granulomatous tuberculosis complicating intravesical BCG for superficial bladder cancer.膀胱内卡介苗治疗浅表性膀胱癌并发肝脏肉芽肿性结核的管理
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Four cases of disseminated Mycobacterium bovis infection following intravesical BCG instillation for treatment of bladder carcinoma.4例膀胱癌患者在膀胱内灌注卡介苗后发生播散性牛分枝杆菌感染。
South Med J. 2008 Jan;101(1):91-5. doi: 10.1097/SMJ.0b013e31815d4047.
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Bladder contracture: review for intravesical bacillus Calmette-Guerin complication.膀胱挛缩:卡介苗膀胱内灌注并发症的综述
Can J Urol. 2007 Dec;14(6):3745-9.