Division of Environmental Medicine and Population Sciences, Department of Social and Environmental Medicine, Graduate School of Medicine, Osaka University, Suita, Osaka, Japan.
Department of Internal Medicine, Faculty of Medicine, Universitas Muhammadiyah Jakarta, Jakarta, Indonesia.
Cancer Prev Res (Phila). 2022 Feb;15(2):101-110. doi: 10.1158/1940-6207.CAPR-21-0224. Epub 2021 Nov 22.
Dietary intake of B vitamins and methionine might associate with carcinogenesis due to their role in DNA synthesis and methylation. Owing to the previous inconsistent findings on gastric cancer risk, we aimed to examine the associations between dietary intakes of B vitamins and methionine and the risk of gastric cancer, according to sodium intake.We included 86,820 Japanese individuals who completed a validated food frequency questionnaire with 138 food items in the Japan Public Health Center-based Prospective Study. Cox proportional hazards regression was used to obtain HRs and 95% confidence intervals (CI) of gastric cancer according to separate intakes of folate, vitamin B6, vitamin B12, and methionine after adjusting for confounding factors, including and atrophic gastritis in the subgroup analysis.We identified 2,269 gastric cancer cases within a median of 15.4 years of follow-up. We found no association between any of the dietary intakes of folate, vitamin B6, vitamin B12, or methionine with the risk of gastric cancer. In the stratified analysis by sodium intake, we observed a positive association between folate intake and risk of gastric cancer among participants with a high sodium intake (≥4.5 g/day) [HR = 1.28 (95% CI, 1.06-1.56), = 0.001; = 0.02]. Meanwhile, there was no association between folate intake and risk of gastric cancer among participants with low sodium intake (<4.5 g/day) [HR = 0.94 (95% CI, 0.73-1.21), = 0.49].In conclusion, we found no association between any dietary intakes of folate, vitamin B6, vitamin B12, and methionine with the risk of gastric cancer. PREVENTION RELEVANCE: The increased intake of B vitamins and methionine in populations with adequate dietary intake of these nutrients showed no association with the risk of gastric cancer.
饮食中摄入 B 族维生素和蛋氨酸可能与致癌作用有关，因为它们在 DNA 合成和甲基化中发挥作用。由于先前关于胃癌风险的研究结果不一致，我们旨在根据钠摄入量，研究饮食中 B 族维生素和蛋氨酸的摄入量与胃癌风险之间的关系。我们纳入了日本公共卫生中心前瞻性研究中完成了包含 138 种食物的经过验证的食物频率问卷的 86820 名日本人。在亚组分析中，通过调整包括萎缩性胃炎在内的混杂因素后，使用 Cox 比例风险回归来获得叶酸、维生素 B6、维生素 B12 和蛋氨酸单独摄入与胃癌风险的 HR 和 95%CI。我们在中位随访 15.4 年后发现了 2269 例胃癌病例。我们没有发现任何一种饮食中叶酸、维生素 B6、维生素 B12 或蛋氨酸的摄入量与胃癌风险之间存在关联。在按钠摄入量分层分析中，我们观察到高钠摄入量（≥4.5g/天）人群中叶酸摄入量与胃癌风险呈正相关[HR=1.28（95%CI，1.06-1.56）， =0.001； =0.02]。同时，低钠摄入量（<4.5g/天）人群中叶酸摄入量与胃癌风险之间没有关联[HR=0.94（95%CI，0.73-1.21）， =0.49]。总之，我们没有发现任何饮食中叶酸、维生素 B6、维生素 B12 和蛋氨酸的摄入量与胃癌风险之间存在关联。预防相关性：在这些营养素的饮食摄入充足的人群中增加 B 族维生素和蛋氨酸的摄入与胃癌风险无关。
