Zeng Fang-fang, Liu Yuan-ting, Lin Xiao-ling, Fan Yu-Ying, Zhang Xing-lan, Xu Chun-hua, Chen Yu-ming
1Guangdong Provincial Key Laboratory of Food, Nutrition and Health,School of Public Health,Sun Yat-sen University,Guangzhou 510080,People's Republic of China.
4Ophthalmic Center,Yat-sen University,Guangzhou 510060,People's Republic of China.
Br J Nutr. 2016 Jan 14;115(1):121-8. doi: 10.1017/S0007114515004146. Epub 2015 Oct 30.
Many studies have suggested that folate-related one-carbon metabolism-related nutrients may play a role in certain cancer risks, but few studies have assessed their associations with the risk for nasopharyngeal carcinoma (NPC). In this study, we investigated the association between four folate-related one-carbon metabolism-related nutrients (folate, vitamin B6, vitamin B12 and methionine) and NPC risk in Chinese adults. A total of 600 patients newly diagnosed (within 3 months) with NPC were individually matched with 600 hospital-based controls by age, sex and household type (urban v. rural). Folate, vitamin B6, vitamin B12 and methionine intakes were measured using a validated seventy-eight-item FFQ. A higher dietary folate or vitamin B6 intake was associated with a lower NPC risk after adjusting for potential confounders. The adjusted OR of NPC for quartiles 2-4 (v. 1) were 0·66 (95% CI 0·48, 0·91), 0·52 (95% CI 0·37, 0·74) and 0·34 (95% CI 0·23, 0·50) (P(trend)<0·001) for folate and 0·72 (95% CI 0·52, 1·00), 0·55 (95% CI 0·39, 0·78) and 0·44 (95% CI 0·30, 0·63) (P(trend)<0·001) for vitamin B6. No significant association with NPC risk was observed for dietary vitamin B12 or methionine intake. The risk for NPC with dietary folate intake was more evident in the participants who were not exposed to toxic substances than in those who were exposed (P(interaction)=0·014). This study suggests that dietary folate and vitamin B6 may be protective for NPC in a high-risk population.
许多研究表明，与叶酸相关的一碳代谢相关营养素可能在某些癌症风险中起作用，但很少有研究评估它们与鼻咽癌（NPC）风险的关联。在本研究中，我们调查了四种与叶酸相关的一碳代谢相关营养素（叶酸、维生素B6、维生素B12和蛋氨酸）与中国成年人NPC风险之间的关联。总共600例新诊断（3个月内）为NPC的患者，按年龄、性别和家庭类型（城市对农村）与600例医院对照个体匹配。使用经过验证的78项食物频率问卷（FFQ）测量叶酸、维生素B6、维生素B12和蛋氨酸的摄入量。在调整潜在混杂因素后，较高的膳食叶酸或维生素B6摄入量与较低的NPC风险相关。叶酸摄入量处于第2-4四分位数（相对于第1四分位数）时，NPC的调整后比值比分别为0·66（95%可信区间0·48，0·91）、0·52（95%可信区间0·37，0·74）和0·34（95%可信区间0·23，0·50）（P趋势<0·001）；维生素B6摄入量处于第2-4四分位数（相对于第1四分位数）时，NPC的调整后比值比分别为0·72（95%可信区间0·52，1·00）、0·55（95%可信区间0·39，0·78）和0·44（95%可信区间0·30，0·63）（P趋势<0·001）。未观察到膳食维生素B12或蛋氨酸摄入量与NPC风险有显著关联。未接触有毒物质的参与者中，膳食叶酸摄入量与NPC风险的关联比接触有毒物质的参与者更明显（P交互作用=0·014）。本研究表明，膳食叶酸和维生素B6可能对高危人群的NPC具有保护作用。
