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自然衰老模型中不同来源脂肪间充质干细胞/干细胞抗肥胖作用的比较

Comparison of Antiobesity Effects of Adipose-Derived Stromal/Stem Cells from Different Sources in a Natural Aging Model.

作者信息

Zhu Yu, Wang Tao, He Shuangli, Pu Shiming, Zhao Hongxia, Zhou Zuping, Wu Qiong

机构信息

School of Life Sciences, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.

Guangxi Universities Key Laboratory of Stem Cell and Biopharmaceutical Technology, Guangxi Normal University, Guilin, Guangxi Zhuang Autonomous Region, People's Republic of China.

出版信息

Diabetes Metab Syndr Obes. 2021 Nov 15;14:4535-4546. doi: 10.2147/DMSO.S334044. eCollection 2021.

DOI:10.2147/DMSO.S334044
PMID:34815680
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8604647/
Abstract

PURPOSE

Our previous study found that white adipose stem cells (W-ASCs) derived from abdominal and femoral sulcus white adipose stem cells (ASCs) have antiaging and age-related obesity effects. Whether interscapular brown adipose stem cells (B-ASCs) have the same effect has not been reported. The study objective was to compare the effects of ASCs from different tissues on aging and aging-related obesity.

PATIENTS AND METHODS

C57BL/6J mice at 22 months of age were transplanted with either B-ASCs or W-ASCs from young mice at 2 months of age. Changes in body weight, biochemistry, cytokines, hormone secretion, cell senescence, lipid metabolism, and ASC function were assessed after transplanted 1 month.

RESULTS

W-ASCs were superior to B-ASCs as aging and age-related obesity indicators, based on change in body weight, organ weight, antioxidant and anti-inflammatory activity, lipid metabolism, and liver and kidney function.

CONCLUSION

Difference in the tissue source was reflected by the heterogeneity of antiaging and age-related obesity effects of transplanted ASCs. Based on the study results, we recommend W-ASCs over B-ASCs in aging and age-related obesity applications.

摘要

目的

我们之前的研究发现，源自腹部和腹股沟沟白色脂肪干细胞（ASCs）的白色脂肪干细胞（W-ASCs）具有抗衰老和抗年龄相关性肥胖的作用。肩胛间棕色脂肪干细胞（B-ASCs）是否具有同样的作用尚未见报道。本研究的目的是比较不同组织来源的ASCs对衰老及衰老相关肥胖的影响。

患者与方法

将2月龄幼鼠的B-ASCs或W-ASCs移植到22月龄的C57BL/6J小鼠体内。移植1个月后评估体重、生化指标、细胞因子、激素分泌、细胞衰老、脂质代谢及ASC功能的变化。

结果

基于体重变化、器官重量、抗氧化和抗炎活性、脂质代谢以及肝肾功能，在衰老和年龄相关性肥胖指标方面，W-ASCs优于B-ASCs。

结论

移植的ASCs抗衰老和抗年龄相关性肥胖作用的异质性反映了组织来源的差异。基于研究结果，在衰老和年龄相关性肥胖应用中，我们推荐使用W-ASCs而非B-ASCs。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/6bf1806f9501/DMSO-14-4535-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/75008fc44a0d/DMSO-14-4535-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/deed1463eea0/DMSO-14-4535-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/e3cec941e8a5/DMSO-14-4535-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/e27e8af6d3ed/DMSO-14-4535-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/983fd04ce015/DMSO-14-4535-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/6bf1806f9501/DMSO-14-4535-g0006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/75008fc44a0d/DMSO-14-4535-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/deed1463eea0/DMSO-14-4535-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/e3cec941e8a5/DMSO-14-4535-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/e27e8af6d3ed/DMSO-14-4535-g0004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/983fd04ce015/DMSO-14-4535-g0005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8f8/8604647/6bf1806f9501/DMSO-14-4535-g0006.jpg

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本文引用的文献

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Obesity (Silver Spring). 2021 Jan;29(1):133-142. doi: 10.1002/oby.23036. Epub 2020 Nov 12.
2
CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice.经CRISPR技术改造的人棕色样脂肪细胞可预防饮食诱导的肥胖，并改善小鼠的代谢综合征。
Sci Transl Med. 2020 Aug 26;12(558). doi: 10.1126/scitranslmed.aaz8664.
3
Impact of Aging on the Characterization of Brown and White Adipose Tissue-Derived Stem Cells in Mice.
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Cells Tissues Organs. 2020;209(1):26-36. doi: 10.1159/000507434. Epub 2020 Jun 11.
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Obesity and ageing: Two sides of the same coin.肥胖与衰老：同一问题的两个方面。
Obes Rev. 2020 Apr;21(4):e12991. doi: 10.1111/obr.12991. Epub 2020 Feb 5.
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The effect of ageing on the resolution of inflammation.衰老对炎症消退的影响。
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Ageing, age-related diseases and oxidative stress: What to do next?衰老、与年龄相关的疾病和氧化应激：下一步该做什么？
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