Goh Ian Y, Mulholland Patricia, Sokolova Anna, Liu Cheng, Siriwardhane Mehan
Department of General Surgery, Mater Hospital, Brisbane, Queensland, Australia.
Faculty of Medicine, University of Queensland, Brisbane, Queensland, Australia.
Ann Med Surg (Lond). 2021 Nov 1;72:103004. doi: 10.1016/j.amsu.2021.103004. eCollection 2021 Dec.
Hepatic small vessel neoplasm (HSVN) is a recently described vascular neoplasm of the liver that can mimic hepatic angiosarcoma (AS) because of its infiltrative nature but is considered biologically less aggressive. We carried out a systematic review of the literature after previously coming across a case of HSVN [1] to guide our surveillance.
We conducted a systematic review for all cases using PubMed, EMBASE, Cochrane Central Register of Controlled Trials, case report journals and Google Scholar according to the PRISMA guidelines using the terms "hepatic small vessel neoplasm" or "hepatic small vessel neoplasia" with no language restrictions. The review was registered with Research Registry (UIN: reviewregistry1127) [2].
We identified 69 articles, of which 6 articles were eligible after screening. A total of 23 cases were identified. Median age was 58 (range 24-83 years) with a male preponderance (17 M:6F). Mean tumour size was 2.8 cm (range 0.2-15.9 cm). Mean follow-up was 7 months (range 1-24 months) with no reported evidence of recurrence in both patient groups with no residual disease or with positive margins after resection.
HSVN appears to demonstrate a benign clinical course with no reported recurrences or metastatic disease. Long-term follow-up data will further supplement our understanding of these tumours and guide future management.
肝小血管肿瘤（HSVN）是一种最近被描述的肝脏血管肿瘤，因其浸润性本质可类似肝血管肉瘤（AS），但被认为生物学行为侵袭性较低。在先前遇到一例HSVN病例后，我们对文献进行了系统回顾，以指导我们的监测。
我们根据PRISMA指南，使用“肝小血管肿瘤”或“肝小血管瘤形成”等术语，在PubMed、EMBASE、Cochrane对照试验中央登记库、病例报告期刊和谷歌学术上对所有病例进行了系统回顾，无语言限制。该综述已在研究注册库注册（UIN：reviewregistry1127）。
我们识别出69篇文章，经筛选后6篇文章符合要求。共识别出23例病例。中位年龄为58岁（范围24 - 83岁），男性占优势（17例男性：6例女性）。平均肿瘤大小为2.8厘米（范围0.2 - 15.9厘米）。平均随访时间为7个月（范围1 - 24个月），在切除后无残留疾病或切缘阳性的两组患者中均未报告复发证据。
HSVN似乎表现出良性临床病程，未报告有复发或转移性疾病。长期随访数据将进一步补充我们对这些肿瘤的理解，并指导未来的管理。
