Barbara Giussy, Buggio Laura, Facchin Federica, Vercellini Paolo
Obstetric and Gynaecologic Emergency Department and SVSeD (Service for Sexual and Domestic Violence), Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, Italy.
Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy.
Front Glob Womens Health. 2021 Sep 27;2:729601. doi: 10.3389/fgwh.2021.729601. eCollection 2021.
Endometriosis is associated with painful symptoms, infertility, sexological difficulties, and psychological suffering. All these symptoms have a negative impact on the overall quality of life of women with the disease, with significant personal, social and economic costs. Several medical options are available to manage symptomatic endometriosis. The pharmacological treatment for endometriosis-related pain may be necessary for decades, or at least until there is a desire for pregnancy or physiologic menopause occurs. In this perspective, clinicians should consider not only the efficacy, but also side effects, tolerability, and costs, along with women's preferences toward different treatments. In this mini-review, we analyzed the pros and cons of the available drugs for the medical therapy of endometriosis, such as estrogen-progestins, progestins, GnRH agonist and GnRH antagonists.
子宫内膜异位症与疼痛症状、不孕、性方面的困难以及心理痛苦相关。所有这些症状都会对患有该疾病的女性的整体生活质量产生负面影响，带来巨大的个人、社会和经济成本。有几种医学方法可用于治疗有症状的子宫内膜异位症。针对子宫内膜异位症相关疼痛的药物治疗可能需要持续数十年，或者至少持续到患者有怀孕意愿或进入生理性绝经。从这个角度来看，临床医生不仅应考虑疗效，还应考虑副作用、耐受性和成本，以及女性对不同治疗方法的偏好。在这篇小型综述中，我们分析了用于子宫内膜异位症药物治疗的现有药物的优缺点，如雌激素 - 孕激素、孕激素、GnRH激动剂和GnRH拮抗剂。
