#COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy of Delta SARS-CoV-2 in a Respiratory Aerosol.

UNLABELLED

We seek to completely revise current models of airborne transmission of respiratory viruses by providing never-before-seen atomic-level views of the SARS-CoV-2 virus within a respiratory aerosol. Our work dramatically extends the capabilities of multiscale computational microscopy to address the significant gaps that exist in current experimental methods, which are limited in their ability to interrogate aerosols at the atomic/molecular level and thus ob-scure our understanding of airborne transmission. We demonstrate how our integrated data-driven platform provides a new way of exploring the composition, structure, and dynamics of aerosols and aerosolized viruses, while driving simulation method development along several important axes. We present a series of initial scientific discoveries for the SARS-CoV-2 Delta variant, noting that the full scientific impact of this work has yet to be realized.

ACM REFERENCE FORMAT

Abigail Dommer , Lorenzo Casalino , Fiona Kearns , Mia Rosenfeld , Nicholas Wauer , Surl-Hee Ahn , John Russo, Sofia Oliveira , Clare Morris , AnthonyBogetti , AndaTrifan , Alexander Brace , TerraSztain , Austin Clyde , Heng Ma , Chakra Chennubhotla , Hyungro Lee , Matteo Turilli , Syma Khalid , Teresa Tamayo-Mendoza , Matthew Welborn , Anders Christensen , Daniel G. A. Smith , Zhuoran Qiao , Sai Krishna Sirumalla , Michael O'Connor , Frederick Manby , Anima Anandkumar , David Hardy , James Phillips , Abraham Stern , Josh Romero , David Clark , Mitchell Dorrell , Tom Maiden , Lei Huang , John McCalpin , Christo- pherWoods , Alan Gray , MattWilliams , Bryan Barker , HarindaRajapaksha , Richard Pitts , Tom Gibbs , John Stone , Daniel Zuckerman *, Adrian Mulholland *, Thomas MillerIII *, ShantenuJha *, Arvind Ramanathan *, Lillian Chong *, Rommie Amaro *. 2021. #COVIDisAirborne: AI-Enabled Multiscale Computational Microscopy ofDeltaSARS-CoV-2 in a Respiratory Aerosol. In . ACM, New York, NY, USA, 14 pages. https://doi.org/finalDOI.