通过铁催化的联烯C(sp)-H官能团化实现联烯与四氢异喹啉的对比耦合。
Contrasteric coupling of allenes and tetrahydroisoquinolines by iron-catalysed allenic C(sp)-H functionalisation.
作者信息
Xia Yue, Wade Nicholas W, Palermo Philip N, Wang Yidong, Wang Yi-Ming
机构信息
Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, USA.
出版信息
Chem Commun (Camb). 2021 Dec 9;57(98):13329-13332. doi: 10.1039/d1cc05949a.
Abstract
An iron-catalysed C-H functionalisation of simple monosubstituted allenes for the synthesis of 1-tetrahydroisoquinolinyl 1,1-disubstituted allenes is reported. This transformation represents the first example of a direct conversion of allenic C-H bonds to C-C bonds through cross dehydrogenative coupling. The optimized protocol features broad scope and employs mild, functional group tolerant conditions.
摘要
报道了一种铁催化的简单单取代丙二烯的C-H官能化反应，用于合成1-四氢异喹啉基-1,1-二取代丙二烯。这种转化代表了通过交叉脱氢偶联将丙二烯C-H键直接转化为C-C键的首例。优化后的方法适用范围广，且采用温和、官能团耐受性好的条件。
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