Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur 721302, India.
Org Biomol Chem. 2021 Dec 15;19(48):10516-10529. doi: 10.1039/d1ob01856f.
Substituted 2-pyridone is one of the most frequent scaffolds among nitrogen-containing bioactive natural products, pharmaceuticals and organic materials. Besides the classical syntheses to construct this class of molecules, retrosynthetically more straightforward approaches based on transition metal catalysed C-H bond functionalizations have been explored recently. In this review, we have summarized the recent progress in the direct transition metal catalysed construction of substituted 2-pyridone scaffolds site-selective C-H bond functionalizations.
取代的 2-吡啶酮是含氮生物活性天然产物、药物和有机材料中最常见的骨架之一。除了构建此类分子的经典合成方法外，最近还探索了基于过渡金属催化 C-H 键功能化的更直接的反合成方法。在本文综述中，我们总结了最近在直接过渡金属催化取代 2-吡啶酮骨架的构建和选择性 C-H 键功能化方面的进展。
