Department of Chemistry, Indian Institute of Technology Kharagpur, Kharagpur, 721302, West Bengal, India.
Chem Rec. 2021 Dec;21(12):3411-3428. doi: 10.1002/tcr.202100061. Epub 2021 Apr 29.
Nitrogen-containing heterocycles are widely found in various biologically active substrates, pharmaceuticals, natural products and organic materials. Consequently, the continuous effort has been devoted towards the development of straightforward, economical, environmentally acceptable, efficient and ingenious methods for the synthesis of various N-containing heterocycles and their functionalizations. Arguably, one of the most prominent direct strategy is regioselective C-H bond functionalizations which provide the step and atom economical approaches in the presence of suitable coupling partners. In this context, site-selective migratory insertion of metal carbenes/nitrenes to the desired C-H bonds has proven as a useful tool to access various functionalized nitrogen heterocycles. In this personal account, we highlight some of our contemporary development toward constructing N-containing heterocycles and their direct functionalizations via transition metal catalysed C-H bond functionalizations based on migratory insertion of metal-carbenes and nitrenes.
含氮杂环广泛存在于各种生物活性底物、药物、天然产物和有机材料中。因此，人们一直在努力开发直接、经济、环境友好、高效和巧妙的方法来合成各种含氮杂环及其官能化。可以说，最突出的直接策略之一是区域选择性 C-H 键功能化，它在合适的偶联伙伴存在下提供了步骤和原子经济性的方法。在这种情况下，金属卡宾/氮宾的选择性迁移插入到所需的 C-H 键已被证明是一种有用的工具，可用于获得各种功能化的氮杂环。在这个个人叙述中，我们强调了我们在通过基于金属卡宾和氮宾迁移插入的过渡金属催化 C-H 键功能化来构建含氮杂环及其直接官能化方面的一些当代发展。
