高迁移率族蛋白 B1 和晚期糖基化终产物受体与急性主动脉夹层患者急性肺损伤的相关性。

Associations of high-mobility group box 1 and receptor for advanced glycation end products with acute lung injury in patient with acute aortic dissection.

机构信息

Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Department of Vascular Surgery - Haikou, China.

Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Medical Care Center, Department of Geriatrics - Haikou, China.

出版信息

Rev Assoc Med Bras (1992). 2021 Sep;67(9):1251-1255. doi: 10.1590/1806-9282.20210395.

DOI:10.1590/1806-9282.20210395

PMID:34816916

Abstract

OBJECTIVE

To investigate the associations of high-mobility group box 1 and its specific receptor, receptor for advanced glycation end products with acute lung injury in patients with acute aortic dissection.

METHODS

A total of 96 acute aortic dissection patients were divided into acute aortic dissection with acute lung injury group (38 cases) and acute aortic dissection without acute lung injury group (58 cases), according to partial pressure of oxygen/fraction of inspired oxygen. In addition, 44 healthy individuals were selected for the control group. The blood samples were taken. The serum high-mobility group box 1 and receptor for advanced glycation end products levels were detected by enzyme-linked immunosorbent assay, and the partial pressure of oxygen/fraction of inspired oxygen was measured.

RESULTS

24 h after admission, the high-mobility group box 1 and receptor for advanced glycation end products levels in acute aortic dissection with acute lung injury and acute aortic dissection without acute lung injury groups were significantly higher than those in the control group, respectively (p<0.05), and each index in acute aortic dissection with acute lung injury group was significantly higher than that in acute aortic dissection without acute lung injury group (p<0.05). At each time point within 96 h after admission, compared with acute aortic dissection without acute lung injury group, in acute aortic dissection with acute lung injury group, the high-mobility group box 1 and receptor for advanced glycation end products levels were increased, respectively, and the partial pressure of oxygen/fraction of inspired oxygen was decreased. The correlation analysis showed that, in acute aortic dissection patients, the high-mobility group box 1 and receptor for advanced glycation end products levels were negatively correlated with partial pressure of oxygen/fraction of inspired oxygen, respectively (p<0.05).

CONCLUSIONS

The serum high-mobility group box 1 and receptor for advanced glycation end products levels may be associated with the occurrence of acute lung injury in acute aortic dissection patients. Monitoring the high-mobility group box 1 and receptor for advanced glycation end products levels can evaluate the risk of acute aortic dissection with acute lung injury.

摘要

目的

探讨高迁移率族蛋白 1（HMGB1）及其特异性受体（晚期糖基化终产物受体，RAGE）与急性主动脉夹层患者急性肺损伤的关系。

方法

选择急性主动脉夹层患者 96 例，根据氧合指数分为急性主动脉夹层合并急性肺损伤组（38 例）和急性主动脉夹层无急性肺损伤组（58 例），另选取同期健康体检者 44 例作为对照组。采集各组血液标本，采用酶联免疫吸附试验检测血清 HMGB1、RAGE 水平，计算氧合指数。

结果

入院 24 h 时，急性主动脉夹层合并急性肺损伤组和急性主动脉夹层无急性肺损伤组患者血清 HMGB1、RAGE 水平均显著高于对照组（p<0.05），且急性主动脉夹层合并急性肺损伤组各指标均显著高于急性主动脉夹层无急性肺损伤组（p<0.05）。入院后 96 h 内各时间点，急性主动脉夹层合并急性肺损伤组患者血清 HMGB1、RAGE 水平均高于急性主动脉夹层无急性肺损伤组，氧合指数均低于急性主动脉夹层无急性肺损伤组，差异均有统计学意义（p<0.05）。相关性分析结果显示，急性主动脉夹层患者血清 HMGB1、RAGE 水平与氧合指数均呈负相关（p<0.05）。